Chemoprevention of Radiation-Induced DNA Double-Strand Breaks with Antioxidants

Kuefner MA, Brand M, Andreassi MG, Braga L, Uder M (2015)

Publication Type: Journal article, Review article

Publication year: 2015

Journal

Current Radiology Reports Springer

Book Volume: 3

Article Number: 81

Journal Issue: 1

DOI: 10.1007/s40134-014-0081-9

Abstract

Double-strand breaks (DSB) are considered to be the most relevant X-ray-induced DNA damages. γ-H2AX immunofluorescence microscopy is a sensitive and reliable method for the quantification of distinct DSB. The detectable amount of these DNA damages correlates well with the dose received. A protective effect of different antioxidants has been postulated. This review explains the principle of the γ-H2AX technique, describes important results concerning DSB in radiologic examinations, and provides an overview on studies evaluating the effect of antioxidants on radiation-induced DNA damages with a special focus on recent studies using the γ-H2AX method.

Authors with CRIS profile

Michael Brand Lehrstuhl für Diagnostische Radiologie Michael Uder Lehrstuhl für Diagnostische Radiologie

Involved external institutions

Istituto di Fisiologia Clinica (IFC) IT Italy (IT) University of North Carolina at Chapel Hill US United States (USA) (US) Krankenhaus Dornbirn AT Austria (AT)

How to cite

APA:

Kuefner, M.A., Brand, M., Andreassi, M.G., Braga, L., & Uder, M. (2015). Chemoprevention of Radiation-Induced DNA Double-Strand Breaks with Antioxidants. Current Radiology Reports, 3(1). https://doi.org/10.1007/s40134-014-0081-9

MLA:

Kuefner, Michael Andreas, et al. "Chemoprevention of Radiation-Induced DNA Double-Strand Breaks with Antioxidants." Current Radiology Reports 3.1 (2015).

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