Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project
Bastiani M, Andersson JLR, Cordero-Grande L, Murgasova M, Hutter J, Price AN, Makropoulos A, Fitzgibbon SP, Hughes E, Rueckert D, Victor S, Rutherford M, Edwards AD, Smith SM, Tournier JD, Hajnal JV, Jbabdi S, Sotiropoulos SN (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 185
Pages Range: 750-763
DOI: 10.1016/j.neuroimage.2018.05.064
Abstract
The developing Human Connectome Project is set to create and make available to the scientific community a 4-dimensional map of functional and structural cerebral connectivity from 20 to 44 weeks post-menstrual age, to allow exploration of the genetic and environmental influences on brain development, and the relation between connectivity and neurocognitive function. A large set of multi-modal MRI data from fetuses and newborn infants is currently being acquired, along with genetic, clinical and developmental information. In this overview, we describe the neonatal diffusion MRI (dMRI) image processing pipeline and the structural connectivity aspect of the project. Neonatal dMRI data poses specific challenges, and standard analysis techniques used for adult data are not directly applicable. We have developed a processing pipeline that deals directly with neonatal-specific issues, such as severe motion and motion-related artefacts, small brain sizes, high brain water content and reduced anisotropy. This pipeline allows automated analysis of in-vivo dMRI data, probes tissue microstructure, reconstructs a number of major white matter tracts, and includes an automated quality control framework that identifies processing issues or inconsistencies. We here describe the pipeline and present an exemplar analysis of data from 140 infants imaged at 38–44 weeks post-menstrual age.
Authors with CRIS profile
Involved external institutions
King’s College London
United Kingdom (GB)
University of Oxford
United Kingdom (GB)
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
United Kingdom (GB)
University of Oxford
United Kingdom (GB)
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
How to cite
APA:
Bastiani, M., Andersson, J.L.R., Cordero-Grande, L., Murgasova, M., Hutter, J., Price, A.N.,... Sotiropoulos, S.N. (2019). Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project. NeuroImage, 185, 750-763. https://doi.org/10.1016/j.neuroimage.2018.05.064
MLA:
Bastiani, Matteo, et al. "Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project." NeuroImage 185 (2019): 750-763.
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