Hutter J, Slator PJ, Jackson L, Gomes ADS, Ho A, Story L, O'Muircheartaigh J, Teixeira RPAG, Chappell LC, Alexander DC, Rutherford MA, Hajnal JV (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 81
Pages Range: 1191-1204
Journal Issue: 2
DOI: 10.1002/mrm.27447
Purpose: To investigate, visualize and quantify the physiology of the human placenta in several dimensions - functional, temporal over gestation, and spatial over the whole organ. Methods: Bespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi-modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two pregnancies diagnosed with pre-eclampsia. Results: A multi-faceted assessment was demonstrated showing trends of increasing lacunarity, and decreasing T2* and diffusivity over gestation. Conclusions: The obtained multi-modal acquisition and quantification shows promising opportunities for studying evolution, adaptation and compensation processes.
APA:
Hutter, J., Slator, P.J., Jackson, L., Gomes, A.D.S., Ho, A., Story, L.,... Hajnal, J.V. (2019). Multi-modal functional MRI to explore placental function over gestation. Magnetic Resonance in Medicine, 81(2), 1191-1204. https://doi.org/10.1002/mrm.27447
MLA:
Hutter, Jana, et al. "Multi-modal functional MRI to explore placental function over gestation." Magnetic Resonance in Medicine 81.2 (2019): 1191-1204.
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