Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

Ng IHX, Bonthrone AF, Kelly CJ, Cordero-Grande L, Hughes EJ, Price AN, Hutter J, Victor S, Schuh A, Rueckert D, Hajnal JV, Simpson J, Edwards AD, Rutherford MA, Batalle D, Counsell SJ (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 10

Article Number: 14909

Journal Issue: 1

DOI: 10.1038/s41598-020-72009-3

Abstract

Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO2) was measured in infants with CHD (n = 49) using phase contrast MR imaging and the relationship between CDO2 and voxel-wise brain structure was assessed using TBM. After correcting for global scaling differences, clusters of significant volume reduction in infants with CHD were demonstrated bilaterally within the basal ganglia, thalami, corpus callosum, occipital, temporal, parietal and frontal lobes, and right hippocampus (p < 0.025 after family-wise error correction). Clusters of significant volume expansion in infants with CHD were identified in cerebrospinal fluid spaces (p < 0.025). After correcting for global brain size, there was no significant association between voxel-wise brain structure and CDO2. This study localizes abnormal brain development in infants with CHD, identifying areas of particular vulnerability.

Authors with CRIS profile

Jana Hutter

Involved external institutions

King’s College London GB United Kingdom (GB) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) St Thomas' Hospital GB United Kingdom (GB)

How to cite

APA:

Ng, I.H.X., Bonthrone, A.F., Kelly, C.J., Cordero-Grande, L., Hughes, E.J., Price, A.N.,... Counsell, S.J. (2020). Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-72009-3

MLA:

Ng, Isabel H. X., et al. "Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry." Scientific Reports 10.1 (2020).

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