Placental magnetic resonance imaging in chronic hypertension: A case-control study
Ho A, Hutter J, Slator P, Jackson L, Seed PT, Mccabe L, Al-Adnani M, Marnerides A, George S, Story L, Hajnal J, Rutherford M, Chappell LC (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 104
Pages Range: 138-145
DOI: 10.1016/j.placenta.2020.12.006
Abstract
Introduction: We aimed to explore the use of magnetic resonance imaging (MRI) in vivo as a tool to elucidate the placental phenotype in women with chronic hypertension. Methods: In case-control study, women with chronic hypertension and those with uncomplicated pregnancies were imaged using either a 3T Achieva or 1.5T Ingenia scanner. T2-weighted images, diffusion weighted and T1/T2* relaxometry data was acquired. Placental T2*, T1 and apparent diffusion coefficient (ADC) maps were calculated. Results: 129 women (43 with chronic hypertension and 86 uncomplicated pregnancies) were imaged at a median of 27.7 weeks’ gestation (interquartile range (IQR) 23.9–32.1) and 28.9 (IQR 26.1–32.9) respectively. Visual analysis of T2-weighted imaging demonstrated placentae to be either appropriate for gestation or to have advanced lobulation in women with chronic hypertension, resulting in a greater range of placental mean T2* values for a given gestation, compared to gestation-matched controls. Both skew and kurtosis (derived from histograms of T2* values across the whole placenta) increased with advancing gestational age at imaging in healthy pregnancies; women with chronic hypertension had values overlapping those in the control group range. Upon visual assessment, the mean ADC declined in the third trimester, with a corresponding decline in placental mean T2* values and showed an overlap of values between women with chronic hypertension and the control group. Discussion: A combined placental MR examination including T2 weighted imaging, T2*, T1 mapping and diffusion imaging demonstrates varying placental phenotypes in a cohort of women with chronic hypertension, showing overlap with the control group.
Authors with CRIS profile
Involved external institutions
King’s College London
United Kingdom (GB)
University College London (UCL)
United Kingdom (GB)
Guy's and St Thomas' (NHS Foundation Trust)
United Kingdom (GB)
United Kingdom (GB)
University College London (UCL)
United Kingdom (GB)
Guy's and St Thomas' (NHS Foundation Trust)
United Kingdom (GB)
How to cite
APA:
Ho, A., Hutter, J., Slator, P., Jackson, L., Seed, P.T., Mccabe, L.,... Chappell, L.C. (2021). Placental magnetic resonance imaging in chronic hypertension: A case-control study. Placenta, 104, 138-145. https://doi.org/10.1016/j.placenta.2020.12.006
MLA:
Ho, Alison, et al. "Placental magnetic resonance imaging in chronic hypertension: A case-control study." Placenta 104 (2021): 138-145.
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