Multi-Channel 4D Parametrized Atlas of Macro- and Microstructural Neonatal Brain Development
Uus A, Grigorescu I, Pietsch M, Batalle D, Christiaens D, Hughes E, Hutter J, Cordero Grande L, Price AN, Tournier JD, Rutherford MA, Counsell SJ, Hajnal JV, Edwards AD, Deprez M (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 15
Article Number: 661704
DOI: 10.3389/fnins.2021.661704
Abstract
Structural (also known as anatomical) and diffusion MRI provide complimentary anatomical and microstructural characterization of early brain maturation. However, the existing models of the developing brain in time include only either structural or diffusion MRI channels. Furthermore, there is a lack of tools for combined analysis of structural and diffusion MRI in the same reference space. In this work, we propose a methodology to generate a multi-channel (MC) continuous spatio-temporal parametrized atlas of the brain development that combines multiple MRI-derived parameters in the same anatomical space during 37–44 weeks of postmenstrual age range. We co-align structural and diffusion MRI of 170 normal term subjects from the developing Human Connectomme Project using MC registration driven by both T2-weighted and orientation distribution functions channels and fit the Gompertz model to the signals and spatial transformations in time. The resulting atlas consists of 14 spatio-temporal microstructural indices and two parcellation maps delineating white matter tracts and neonatal transient structures. In order to demonstrate applicability of the atlas for quantitative region-specific studies, a comparison analysis of 140 term and 40 preterm subjects scanned at the term-equivalent age is performed using different MRI-derived microstructural indices in the atlas reference space for multiple white matter regions, including the transient compartments. The atlas and software will be available after publication of the article1.
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APA:
Uus, A., Grigorescu, I., Pietsch, M., Batalle, D., Christiaens, D., Hughes, E.,... Deprez, M. (2021). Multi-Channel 4D Parametrized Atlas of Macro- and Microstructural Neonatal Brain Development. Frontiers in Neuroscience, 15. https://doi.org/10.3389/fnins.2021.661704
MLA:
Uus, Alena, et al. "Multi-Channel 4D Parametrized Atlas of Macro- and Microstructural Neonatal Brain Development." Frontiers in Neuroscience 15 (2021).
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