The developing brain structural and functional connectome fingerprint

Ciarrusta J, Christiaens D, Fitzgibbon SP, Dimitrova R, Hutter J, Hughes E, Duff E, Price AN, Cordero-Grande L, Tournier JD, Rueckert D, V. Hajnal J, Arichi T, Mcalonan G, Edwards D, Batalle D (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Developmental Cognitive Neuroscience Elsevier BV

Book Volume: 55

Article Number: 101117

DOI: 10.1016/j.dcn.2022.101117

Abstract

In the mature brain, structural and functional ‘fingerprints’ of brain connectivity can be used to identify the uniqueness of an individual. However, whether the characteristics that make a given brain distinguishable from others already exist at birth remains unknown. Here, we used neuroimaging data from the developing Human Connectome Project (dHCP) of preterm born neonates who were scanned twice during the perinatal period to assess the developing brain fingerprint. We found that 62% of the participants could be identified based on the congruence of the later structural connectome to the initial connectivity matrix derived from the earlier timepoint. In contrast, similarity between functional connectomes of the same subject at different time points was low. Only 10% of the participants showed greater self-similarity in comparison to self-to-other-similarity for the functional connectome. These results suggest that structural connectivity is more stable in early life and can represent a potential connectome fingerprint of the individual: a relatively stable structural connectome appears to support a changing functional connectome at a time when neonates must rapidly acquire new skills to adapt to their new environment.

Authors with CRIS profile

Jana Hutter

Involved external institutions

King’s College London GB United Kingdom (GB) University of Oxford GB United Kingdom (GB) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB)

How to cite

APA:

Ciarrusta, J., Christiaens, D., Fitzgibbon, S.P., Dimitrova, R., Hutter, J., Hughes, E.,... Batalle, D. (2022). The developing brain structural and functional connectome fingerprint. Developmental Cognitive Neuroscience, 55. https://doi.org/10.1016/j.dcn.2022.101117

MLA:

Ciarrusta, Judit, et al. "The developing brain structural and functional connectome fingerprint." Developmental Cognitive Neuroscience 55 (2022).

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