Hutter J, Slator PJ, Zampieri CA, Hall M, Rutherford M, Story L (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 89
Pages Range: 1151-1159
Journal Issue: 3
DOI: 10.1002/mrm.29483
Purpose: Preterm premature rupture of membranes complicates up to 40% of premature deliveries. Fetal infection may occur in the absence of maternal symptoms, delaying diagnosis and increasing morbidity and mortality. A noninvasive antenatal assessment of early signs of placental inflammation is therefore urgently required. Methods: Sixteen women with preterm premature rupture of membranes < 34 weeks gestation and 60 women with uncomplicated pregnancies were prospectively recruited. A modified diffusion-weighted spin-echo single shot EPI sequence with a diffusion preparation acquiring 264 unique parameter combinations in < 9 min was obtained on a clinical 3 Tesla MRI scanner. The data was fitted to a 2-compartment (Formula presented.) -intravoxel incoherent motion model comprising fast and slowly circulating fluid pools to obtain quantitative information on perfusion, density, and tissue composition. Z values were calculated, and correlation with time from between the rupture of membranes and the scan, gestational age at delivery, and time between scan and delivery assessed. Results: Placental (Formula presented.) was significantly reduced in preterm premature rupture of membranes, and the 2-compartmental model demonstrated that this decline is mainly linked to the perfusion component observed in the placental parenchyma. Multi-modal MRI measurement of placental function is linked to gestational age at delivery and time from membrane rupture. Conclusion: More complex models and data acquisition can potentially improve fitting of the underlying etiology of preterm birth compared with individual single-contrast models and contribute to additional insights in the future. This will need validation in larger cohorts. A multi-modal MRI acquisition between rupture of the membranes and delivery can be used to measure placental function and is linked to gestational age at delivery.
APA:
Hutter, J., Slator, P.J., Zampieri, C.A., Hall, M., Rutherford, M., & Story, L. (2023). Multi-modal MRI reveals changes in placental function following preterm premature rupture of membranes. Magnetic Resonance in Medicine, 89(3), 1151-1159. https://doi.org/10.1002/mrm.29483
MLA:
Hutter, Jana, et al. "Multi-modal MRI reveals changes in placental function following preterm premature rupture of membranes." Magnetic Resonance in Medicine 89.3 (2023): 1151-1159.
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