Deciphering the Role of Heme Oxygenase-1 (HO-1) Expressing Macrophages in Renal Ischemia-Reperfusion Injury.
Rossi M, Korpak K, Doerfler A, Zouaoui Boudjeltia K (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Book Volume: 9
Journal Issue: 3
DOI: 10.3390/biomedicines9030306
Abstract
Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). Renal IRI combines major events, including a strong inflammatory immune response leading to extensive cell injuries, necrosis and late interstitial fibrosis. Macrophages act as key players in IRI-induced AKI by polarizing into proinflammatory M1 and anti-inflammatory M2 phenotypes. Compelling evidence exists that the stress-responsive enzyme, heme oxygenase-1 (HO-1), mediates protection against renal IRI and modulates macrophage polarization by enhancing a M2 subset. Hereafter, we review the dual effect of macrophages in the pathogenesis of IRI-induced AKI and discuss the critical role of HO-1 expressing macrophages.
Involved external institutions
Belgium (BE)How to cite
APA:
Rossi, M., Korpak, K., Doerfler, A., & Zouaoui Boudjeltia, K. (2021). Deciphering the Role of Heme Oxygenase-1 (HO-1) Expressing Macrophages in Renal Ischemia-Reperfusion Injury. Biomedicines, 9(3). https://dx.doi.org/10.3390/biomedicines9030306
MLA:
Rossi, Maxime, et al. "Deciphering the Role of Heme Oxygenase-1 (HO-1) Expressing Macrophages in Renal Ischemia-Reperfusion Injury." Biomedicines 9.3 (2021).
BibTeX: Download