Itching in Atopic Dermatitis: Patient-and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany

Weisshaar E, Bentz P, Apfelbacher C, Haufe E, Heinrich L, Heratizadeh A, Abraham S, Harder I, Kleinheinz A, Wollenberg A, Schäkel K, Wiemers F, Ertner J, Augustin M, Wildberger J, von KIEDROWSKI R, Worm M, Zink A, Effendy I, Asmussen A, Pawlak M, Sticherling M, Hilgers M, Handrick C, Quist S, Schwarz B, Bell M, Staubach-Renz P, Hong-Weldemann SH, Homey B, Brücher JJ, Weidinger S, Werfel T, Schmitt J (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Acta Dermato-Venereologica Society for Publication of Acta Dermato-Venereologica

Book Volume: 103

Article Number: adv00854

DOI: 10.2340/actadv.v103.4426

Abstract

TREATgermany is an investigator-initiated prospective disease registry. It investigates physician-and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symptoms (itch, sleep loss, depressive symptoms), therapy courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 ± 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The cur-rent analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the pre-vious 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39–0.48)) and EASI score (rho = 0.41 (0.36–0.46)). A strong cor-relation was found with self-reported disease severity as PGA (rho = 0.68 (0.65–0.71)), POEM sum score (rho = 0.66 (0.63–0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57–0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assessments by the physician.

Authors with CRIS profile

Michael Sticherling Professur für Dermatologie

Additional Organisation(s)

FAU Profilzentrum Licht.Materie.Quantentechnologien (FAU LMQ)

Involved external institutions

Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Otto-von-Guericke-Universität Magdeburg DE Germany (DE) Universitätsklinikum Carl Gustav Carus Dresden DE Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Elbe Kliniken Stade-Buxtehude DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Universität Bielefeld DE Germany (DE) Universitätsklinikum Aachen (UKA) DE Germany (DE) Helix Mainz GmbH & Co. KG DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Universitätsklinikum Düsseldorf DE Germany (DE) Universitätsmedizin der Johannes Gutenberg-Universität Mainz DE Germany (DE)

How to cite

APA:

Weisshaar, E., Bentz, P., Apfelbacher, C., Haufe, E., Heinrich, L., Heratizadeh, A.,... Schmitt, J. (2023). Itching in Atopic Dermatitis: Patient-and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany. Acta Dermato-Venereologica, 103. https://doi.org/10.2340/actadv.v103.4426

MLA:

Weisshaar, Elke, et al. "Itching in Atopic Dermatitis: Patient-and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany." Acta Dermato-Venereologica 103 (2023).

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