Update Breast Cancer 2022 Part 4 - Advanced-Stage Breast Cancer.

Aktas B, Fehm TN, Welslau M, Mueller V, Lueftner D, Schuetz F, Fasching P, Janni W, Thomssen C, Witzel I, Belleville E, Untch M, Thill M, Tesch H, Ditsch N, Lux MP, Banys-Paluchowski M, Kolberg-Liedtke C, Hartkopf AD, Woeckel A, Kolberg HC, Stickeler E, Harbeck N, Schneeweiss A (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

Book Volume: 82

Pages Range: 922-931

Journal Issue: 9

DOI: 10.1055/a-1912-7362

Abstract

For the treatment of patients with advanced HER2-negative hormone receptor-positive breast cancer, several substances have been introduced into practice in recent years. In addition, other drugs are under development. A number of studies have been published over the past year which have shown either an advantage for progression-free survival or for overall survival. This review summarizes the latest results, which have been published at current congresses or in specialist journals, and classifies them in the clinical treatment context. In particular, the importance of therapy with CDK4/6 inhibitors - trastuzumab deruxtecan, sacituzumab govitecan and capivasertib - is discussed. For trastuzumab deruxtecan, an overall survival benefit in HER2-negative breast cancer with low HER2 expression (HER2-low expression) was reported in the Destiny-Breast-04 study. Similarly, there was an overall survival benefit in the FAKTION study with capivasertib. The lack of overall survival benefit for palbociclib in the first line of therapy raises the question of clinical classification.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Augsburg Germany (DE) Martin-Luther-Universität Halle-Wittenberg (MLU) Germany (DE) Diakonissen-Stiftungs-Krankenhaus Speyer Germany (DE) Universitätsklinikum Aachen (UKA) Germany (DE) Onkologie Aschaffenburg Germany (DE) Universitätsklinikum Ulm Germany (DE) Marienhospital Bottrop Germany (DE) Universitätsklinikum Essen Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) HELIOS Kliniken Germany (DE) Immanuel Klinik Märkische Schweiz Germany (DE) Universität Leipzig Germany (DE) Klinikum der Universität München Germany (DE) Centrum für Hämatologie und Onkologie Bethanien Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) Universitätsklinikum Würzburg Germany (DE) Agaplesion Markus Krankenhaus Germany (DE) Universitätsklinikum Düsseldorf Germany (DE) ClinSol GmbH & Co.KG Germany (DE) Universitätsklinikum Heidelberg Germany (DE) St. Vincenz-Krankenhaus Germany (DE)

How to cite

APA:

Aktas, B., Fehm, T.N., Welslau, M., Mueller, V., Lueftner, D., Schuetz, F.,... Schneeweiss, A. (2022). Update Breast Cancer 2022 Part 4 - Advanced-Stage Breast Cancer. Geburtshilfe und Frauenheilkunde, 82(9), 922-931. https://doi.org/10.1055/a-1912-7362

MLA:

Aktas, Bahriye, et al. "Update Breast Cancer 2022 Part 4 - Advanced-Stage Breast Cancer." Geburtshilfe und Frauenheilkunde 82.9 (2022): 922-931.

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