Update Breast Cancer 2021 Part 5 - Advanced Breast Cancer.

Lueftner D, Schuetz F, Stickeler E, Fasching P, Janni W, Kolberg-Liedtke C, Kolberg HC, Thomssen C, Mueller V, Fehm TN, Belleville E, Bader S, Untch M, Welslau M, Thill M, Tesch H, Ditsch N, Lux MP, Woeckel A, Aktas B, Schneeweiss A, Wuerstlein R, Hartkopf AD (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

Book Volume: 82

Pages Range: 215-225

Journal Issue: 2

DOI: 10.1055/a-1724-9569

Abstract

Despite the COVID 19 pandemic and mostly virtual congresses, innovation in the treatment of breast cancer patients continues at an unabated pace. This review summarises the current developments. Initial overall survival data for CDK4/6 inhibitor treatment in combination with an aromatase inhibitor as the first advanced line of therapy in treatment-naive postmenopausal patients have been published. Similarly, a trial comparing trastuzumab-deruxtecan versus trastuzumab-emtansine revealed a clear benefit regarding progression-free survival. Understanding of biomarkers making checkpoint inhibitor therapy particularly effective is increasing, and new compounds such as oral selective estrogen receptor destabilisers (SERDs) are entering clinical development and completing the first phase III trials.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Heidelberg Germany (DE) Diakonissen-Stiftungs-Krankenhaus Speyer Germany (DE) Centrum für Hämatologie und Onkologie Bethanien Germany (DE) Agaplesion Markus Krankenhaus Germany (DE) ClinSol GmbH & Co.KG Germany (DE) Klinikum der Universität München Germany (DE) Martin-Luther-Universität Halle-Wittenberg (MLU) Germany (DE) Universitätsklinikum Düsseldorf Germany (DE) Universitätsklinikum Leipzig Germany (DE) Eberhard Karls Universität Tübingen Germany (DE) Universitätsklinikum Ulm Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Universitätsklinikum Aachen (UKA) Germany (DE) Universitätsklinikum Essen Germany (DE) Universitätsklinikum Augsburg Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Universitätsklinikum Würzburg Germany (DE) Marienhospital Bottrop Germany (DE) HELIOS Kliniken Germany (DE) St. Vincenz-Krankenhaus Germany (DE)

How to cite

APA:

Lueftner, D., Schuetz, F., Stickeler, E., Fasching, P., Janni, W., Kolberg-Liedtke, C.,... Hartkopf, A.D. (2022). Update Breast Cancer 2021 Part 5 - Advanced Breast Cancer. Geburtshilfe und Frauenheilkunde, 82(2), 215-225. https://doi.org/10.1055/a-1724-9569

MLA:

Lueftner, Diana, et al. "Update Breast Cancer 2021 Part 5 - Advanced Breast Cancer." Geburtshilfe und Frauenheilkunde 82.2 (2022): 215-225.

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