Cytocompatibility of siloxane-containing vaterite/Poly(L-lactic acid) composite coatings on metallic magnesium

Yamada S, Maeda H, Obata A, Lohbauer U, Yamamoto A, Kasuga T (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Materials MDPI

Book Volume: 6

Pages Range: 5857-5869

Journal Issue: 12

DOI: 10.3390/ma6125857

Abstract

Poly(L-lactic acid)-based films which include 60 wt % of vaterite (V) or siloxane-containing vaterite (SiV) were coated on a pure magnesium substrate, denoted by PLLA/V or PLLA/SiV, respectively, to suppress early corrosion and improve its cytocompatibility. Both coating films adhered to the Mg substrate with 2.3-2.8 MPa of tensile bonding strength. Soaking test for 7 days in α-modified minimum essential medium revealed that the morphological instability of the PLLA/V film caused a higher amount of Mg2+ ion to be released from the coating sample. On the other hand, in the case of the coating with the PLLA/SiV film, no morphological change even after the soaking test was observed, owing to the suppression of the degradation rate. In cell culture tests, the proliferation of mouse osteoblast-like cell (MC3T3-E1) was significantly enhanced by both coatings, in comparison with the uncoated magnesium substrate. The cell morphology revealed that a few less-spread cells were observed on the PLLA/V film, while more elongated cells were done on the PLLA/SiV film. The cells on the PLLA/SiV film exhibited an extremely higher alkaline phosphatase activity after 21 days of incubation than that on the PLLA/V one. The PLLA/SiV film suppressed the early corrosion and enhanced cytocompatibility on metallic magnesium. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

Authors with CRIS profile

Ulrich Lohbauer Medizinische Fakultät

Involved external institutions

Nagoya Institute of Technology / 名古屋工業大学 Nagoya Kōgyō Daigaku JP Japan (JP) National Institute of Materials Science (NIMS) JP Japan (JP)

How to cite

APA:

Yamada, S., Maeda, H., Obata, A., Lohbauer, U., Yamamoto, A., & Kasuga, T. (2013). Cytocompatibility of siloxane-containing vaterite/Poly(L-lactic acid) composite coatings on metallic magnesium. Materials, 6(12), 5857-5869. https://doi.org/10.3390/ma6125857

MLA:

Yamada, Shinya, et al. "Cytocompatibility of siloxane-containing vaterite/Poly(L-lactic acid) composite coatings on metallic magnesium." Materials 6.12 (2013): 5857-5869.

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