Merkel S, Brunner M, Geppert CI, Grützmann R, Weber K, Agaimy A (2022)
Publication Type: Journal article
Publication year: 2022
Book Volume: 14
Journal Issue: 24
The TNM classification system is one of the most important factors determining prognosis for cancer patients. In colorectal cancer, the T category reflects the depth of tumor invasion. T3 is defined by a tumor that invades through the muscularis propria into pericolorectal tissues. The data of 1047 patients with complete mesocolic excision were analyzed. The depth of invasion beyond the outer border of the muscularis propria into the subserosa or into nonperitonealized pericolic tissue was measured and categorized in 655 pT3 patients: pT3a (≤1 mm), pT3b,c (>1-15 mm) and pT3d (>15 mm). The prognosis of these categories was compared. Five-year distant metastasis increased significantly from pT3a (5.7%) over pT3b,c (17.7%) to pT3d (37.2%; p = 0.001). There was no difference between pT2 (5.3%) and pT3a or between pT3d and pT4a (42.1%) or pT4b (33.7%). The 5-year disease-free survival decreased significantly from pT3a (77.4%) over pT3b,c (65.4%) to pT3d (50.1%; p = 0.015). No significant difference was found between pT2 (80.5%) and pT3a or between pT3d and pT4a (43.9%; p = 0.296) or pT4b (53.4%). The prognostic inhomogeneity in pT3 colon carcinoma has been demonstrated. A three-level subdivision of T3 for colon carcinoma in the TNM system into T3a (≤1 mm), T3b (>1-15 mm), and T3c (>15 mm) is recommended.
APA:
Merkel, S., Brunner, M., Geppert, C.-I., Grützmann, R., Weber, K., & Agaimy, A. (2022). Proposal of a T3 Subclassification for Colon Carcinoma. Cancers, 14(24). https://doi.org/10.3390/cancers14246186
MLA:
Merkel, Susanne, et al. "Proposal of a T3 Subclassification for Colon Carcinoma." Cancers 14.24 (2022).
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