Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I, Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S, Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ, Belkaid Y (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Cell Elsevier

Book Volume: 172

Pages Range: 784-796.e18

Journal Issue: 4

DOI: 10.1016/j.cell.2017.12.033

Abstract

Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We explored how the microbiota was sensed by the immune system and the defining properties of such responses. Here, we show that a skin commensal can induce T cell responses in a manner that is restricted to non-classical MHC class I molecules. These responses are uncoupled from inflammation and highly distinct from pathogen-induced cells. Commensal-specific T cells express a defined gene signature that is characterized by expression of effector genes together with immunoregulatory and tissue-repair signatures. As such, non-classical MHCI-restricted commensal-specific immune responses not only promoted protection to pathogens, but also accelerated skin wound closure. Thus, the microbiota can induce a highly physiological and pleiotropic form of adaptive immunity that couples antimicrobial function with tissue repair. Our work also reveals that non-classical MHC class I molecules, an evolutionarily ancient arm of the immune system, can promote homeostatic immunity to the microbiota. Microbiota induce a form of adaptive immunity that couples antimicrobial function with tissue repair.

Authors with CRIS profile

Stephan Patrick Rosshart

Involved external institutions

US National Institutes of Health (NIH) US United States (USA) (US) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) US United States (USA) (US) National Cancer Institute (NCI) US United States (USA) (US) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK / NIDDKD) US United States (USA) (US) Northwestern University US United States (USA) (US)

How to cite

APA:

Linehan, J.L., Harrison, O.J., Han, S.-J., Byrd, A.L., Vujkovic-Cvijin, I., Villarino, A.V.,... Belkaid, Y. (2018). Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair. Cell, 172(4), 784-796.e18. https://dx.doi.org/10.1016/j.cell.2017.12.033

MLA:

Linehan, Jonathan L., et al. "Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair." Cell 172.4 (2018): 784-796.e18.

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