Tamoutounour S, Han SJ, Deckers J, Constantinides MG, Hurabielle C, Harrison OJ, Bouladoux N, Linehan JL, Link VM, Vujkovic-Cvijin I, Perez-Chaparro PJ, Rosshart SP, Rehermann B, Lazarevic V, Belkaid Y (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 116
Pages Range: 23643-23652
Journal Issue: 47
The cross-talk between the microbiota and the immune system plays a fundamental role in the control of host physiology. However, the tissue-specific factors controlling this dialogue remain poorly understood. Here we demonstrate that T cell responses to commensal colonization are associated with the development of organized cellular clusters within the skin epithelium. These organized lymphocyte clusters are surrounded by keratinocytes expressing a discrete program associated with antigen presentation and antimicrobial defense. Notably, IL-22–mediated keratinocyte-intrinsic MHC class II expression was required for the selective accumulation of commensal-induced IFN-γ, but not IL-17A–producing CD4+ T cells within the skin. Taking these data together, this work uncovers an unexpected role for MHC class II expression by keratinocytes in the control of homeostatic type 1 responses to the microbiota. Our findings have important implications for the understanding of the tissue-specific rules governing the dialogue between a host and its microbiota.
APA:
Tamoutounour, S., Han, S.-J., Deckers, J., Constantinides, M.G., Hurabielle, C., Harrison, O.J.,... Belkaid, Y. (2019). Keratinocyte-intrinsic MHCII expression controls microbiota-induced Th1 cell responses. Proceedings of the National Academy of Sciences of the United States of America, 116(47), 23643-23652. https://dx.doi.org/10.1073/pnas.1912432116
MLA:
Tamoutounour, Samira, et al. "Keratinocyte-intrinsic MHCII expression controls microbiota-induced Th1 cell responses." Proceedings of the National Academy of Sciences of the United States of America 116.47 (2019): 23643-23652.
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