A Compilation of Study Models for Dental Pulp Regeneration

Ohlsson E, Galler KM, Widbiller M (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 23

Article Number: 14361

Journal Issue: 22

DOI: 10.3390/ijms232214361

Abstract

Efforts to heal damaged pulp tissue through tissue engineering have produced positive results in pilot trials. However, the differentiation between real regeneration and mere repair is not possible through clinical measures. Therefore, preclinical study models are still of great importance, both to gain insights into treatment outcomes on tissue and cell levels and to develop further concepts for dental pulp regeneration. This review aims at compiling information about different in vitro and in vivo ectopic, semiorthotopic, and orthotopic models. In this context, the differences between monolayer and three-dimensional cell cultures are discussed, a semiorthotopic transplantation model is introduced as an in vivo model for dental pulp regeneration, and finally, different animal models used for in vivo orthotopic investigations are presented.

Authors with CRIS profile

Ella Ohlsson Department of Operative Dentistry and Periodontology Kerstin Martina Galler Lehrstuhl für Zahn-,Mund- und Kieferheilkunde, insbesondere Zahnerhaltung, Parodontologie und Kinderzahnheilkunde

Involved external institutions

Universitätsklinikum Regensburg DE Germany (DE)

How to cite

APA:

Ohlsson, E., Galler, K.M., & Widbiller, M. (2022). A Compilation of Study Models for Dental Pulp Regeneration. International Journal of Molecular Sciences, 23(22). https://doi.org/10.3390/ijms232214361

MLA:

Ohlsson, Ella, Kerstin Martina Galler, and Matthias Widbiller. "A Compilation of Study Models for Dental Pulp Regeneration." International Journal of Molecular Sciences 23.22 (2022).

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