Rector JL, Thomas GN, Burns VE, Dowd JB, Herr RM, Moss PA, Jarczok MN, Hoffman K, Fischer JE, Bosch JA (2015)
Publication Type: Journal article
Publication year: 2015
Book Volume: 58
Pages Range: 2596-2605
Journal Issue: 11
DOI: 10.1007/s00125-015-3731-4
Aims/hypothesis: Biological ageing of the immune system, or immunosenescence, predicts poor health and increased mortality. A hallmark of immunosenescence is the accumulation of differentiated cytotoxic T cells (CD27−CD45RA+/−; or dCTLs), partially driven by infection with the cytomegalovirus (CMV). Immune impairments reminiscent of immunosenescence are also observed in hyperglycaemia, and in vitro studies have illustrated mechanisms by which elevated glucose can lead to increased dCTLs. This study explored associations between glucose dysregulation and markers of immunosenescence in CMV+ and CMV− individuals. Methods: A cross-sectional sample of participants from an occupational cohort study (n = 1,103, mean age 40 years, 88% male) were assessed for HbA
APA:
Rector, J.L., Thomas, G.N., Burns, V.E., Dowd, J.B., Herr, R.M., Moss, P.A.,... Bosch, J.A. (2015). Elevated HbA1c levels and the accumulation of differentiated T cells in CMV+ individuals. Diabetologia, 58(11), 2596-2605. https://doi.org/10.1007/s00125-015-3731-4
MLA:
Rector, Jerrald L., et al. "Elevated HbA1c levels and the accumulation of differentiated T cells in CMV+ individuals." Diabetologia 58.11 (2015): 2596-2605.
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