Increased global interaction across functional brain modules during cognitive emotion regulation

Brandl F, Bratec SM, Xie X, Wohlschlager AM, Riedl V, Meng C, Sorg C (2018)


Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 28

Pages Range: 3282-3294

Journal Issue: 9

DOI: 10.1093/cercor/bhx178

Abstract

Cognitive emotion regulation (CER) enables humans to flexibly modulate their emotions. While local theories of CER neurobiology suggest interactions between specialized local brain circuits underlying CER, e.g., in subparts of amygdala and medial prefrontal cortices (mPFC), global theories hypothesize global interaction increases among larger functional brain modules comprising local circuits. We tested the global CER hypothesis using graph-based whole-brain network analysis of functional MRI data during aversive emotional processing with and without CER. During CER, global between-module interaction across stable functional network modules increased. Global interaction increase was particularly driven by subregions of amygdala and cuneus—nodes of highest nodal participation—that overlapped with CER-specific local activations, and by mPFC and posterior cingulate as relevant connector hubs. Results provide evidence for the global nature of human CER, complementing functional specialization of embedded local brain circuits during successful CER.

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APA:

Brandl, F., Bratec, S.M., Xie, X., Wohlschlager, A.M., Riedl, V., Meng, C., & Sorg, C. (2018). Increased global interaction across functional brain modules during cognitive emotion regulation. Cerebral Cortex, 28(9), 3282-3294. https://doi.org/10.1093/cercor/bhx178

MLA:

Brandl, Felix, et al. "Increased global interaction across functional brain modules during cognitive emotion regulation." Cerebral Cortex 28.9 (2018): 3282-3294.

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