Common and distinct changes of default mode and salience network in schizophrenia and major depression
Shao J, Meng C, Tahmasian M, Brandl F, Yang Q, Luo G, Luo C, Yao D, Gao L, Riedl V, Wohlschlaeger A, Sorg C (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 12
Pages Range: 1708-1719
Journal Issue: 6
DOI: 10.1007/s11682-018-9838-8
Abstract
Brain imaging reveals schizophrenia as a disorder of macroscopic brain networks. In particular, default mode and salience network (DMN, SN) show highly consistent alterations in both interacting brain activity and underlying brain structure. However, the same networks are also altered in major depression. This overlap in network alterations induces the question whether DMN and SN changes are different across both disorders, potentially indicating distinct underlying pathophysiological mechanisms. To address this question, we acquired T1-weighted, diffusion-weighted, and resting-state functional MRI in patients with schizophrenia, patients with major depression, and healthy controls. We measured regional gray matter volume, inter-regional structural and intrinsic functional connectivity of DMN and SN, and compared these measures across groups by generalized Wilcoxon rank tests, while controlling for symptoms and medication. When comparing patients with controls, we found in each patient group SN volume loss, impaired DMN structural connectivity, and aberrant DMN and SN functional connectivity. When comparing patient groups, SN gray matter volume loss and DMN structural connectivity reduction did not differ between groups, but in schizophrenic patients, functional hyperconnectivity between DMN and SN was less in comparison to depressed patients. Results provide evidence for distinct functional hyperconnectivity between DMN and SN in schizophrenia and major depression, while structural changes in DMN and SN were similar. Distinct hyperconnectivity suggests different pathophysiological mechanism underlying aberrant DMN-SN interactions in schizophrenia and depression.
Authors with CRIS profile
Involved external institutions
Shahid Beheshti University of Medical Sciences
Iran, Islamic Republic of (IR)
Technische Universität München (TUM)
Germany (DE)
University of Electronic Science and Technology of China (UESTC) / 电子科技大学
China (CN)
Klinikum rechts der Isar
Germany (DE)
Iran, Islamic Republic of (IR)
Technische Universität München (TUM)
Germany (DE)
University of Electronic Science and Technology of China (UESTC) / 电子科技大学
China (CN)
Klinikum rechts der Isar
Germany (DE)
How to cite
APA:
Shao, J., Meng, C., Tahmasian, M., Brandl, F., Yang, Q., Luo, G.,... Sorg, C. (2018). Common and distinct changes of default mode and salience network in schizophrenia and major depression. Brain Imaging and Behavior, 12(6), 1708-1719. https://dx.doi.org/10.1007/s11682-018-9838-8
MLA:
Shao, Junming, et al. "Common and distinct changes of default mode and salience network in schizophrenia and major depression." Brain Imaging and Behavior 12.6 (2018): 1708-1719.
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