Breast ultrasound elastography-results of 193 breast lesions in a prospective study with histopathologic correlation
Schaefer FKW, Heer I, Schaefer PJ, Mundhenke C, Osterholz S, Order BM, Hofheinz N, Hedderich J, Heller M, Jonat W, Schreer I (2011)
Publication Type: Journal article
Publication year: 2011
Journal
Book Volume: 77
Pages Range: 450-456
Journal Issue: 3
DOI: 10.1016/j.ejrad.2009.08.026
Abstract
Purpose: To evaluate the diagnostic performance of ultrasound elastography in breast masses. Material and methods: 193 lesions (129 benign, 64 malignant) were analyzed with the EUB 8500 Logos-ultrasonic-unit (Hitachi Medical, Japan) and a linear-array-transducer of 7.5-13-MHz. Standard of reference was cytology (FNAfine needle aspiration) or histology (core biopsy). The elastic-score was classified according to a 6-point colour-scale (Ueno classification; 1-3 = benign, 4-5 = malignant). Conventional B-mode ultrasound (US) findings were classified according to the BI-RADS classification. Statistical analysis included sensitivity, specificity, ROC-analysis and kappa-values for intra-/interobserver reliability. Results: The mean score for elasticity was 4.1 ± 0.9 for malignant lesions, and 2.1 ± 1.0 for benign lesions (p < 0.001). With a best cut-off point between elasticity scores 3 and 4, sensitivity was 96.9%, and specificity 76%. Setting a best cut-off point for conventional US between BI-RADS 4 and 5, sensitivity was 57.8%, and specificity 96.1%. Elastography provided higher sensitivity and lower specificity than conventional US, but two lesions with elasticity score 1 were false negative, whereas no lesion scored BI-RADS 1-3 were false negative. ROC-curve was 0.884 for elastography, and 0.820 for conventional US (p < 0.001). Weighted kappa-values for intra-/interobserver reliability were 0.784/0.634 for BI-RADS classification, and 0.720/0.561 for elasticity scores. Conclusion: In our study setting, elastography does not have the potential to replace conventional B-mode US for the detection of breast cancer, but may complement conventional US to improve the diagnostic performance. © 2009 Elsevier Ireland Ltd. All rights reserved.
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APA:
Schaefer, F.K.W., Heer, I., Schaefer, P.J., Mundhenke, C., Osterholz, S., Order, B.M.,... Schreer, I. (2011). Breast ultrasound elastography-results of 193 breast lesions in a prospective study with histopathologic correlation. European Journal of Radiology, 77(3), 450-456. https://doi.org/10.1016/j.ejrad.2009.08.026
MLA:
Schaefer, F. K. W., et al. "Breast ultrasound elastography-results of 193 breast lesions in a prospective study with histopathologic correlation." European Journal of Radiology 77.3 (2011): 450-456.
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