Vulvar cancer: Epidemiology, clinical presentation, and management options
Alkatout I, Schubert M, Garbrecht N, Weigel MT, Jonat W, Mundhenke C, Günther V (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 7
Pages Range: 305-313
DOI: 10.2147/IJWH.S68979
Abstract
Epidemiology: Vulvar cancer can be classified into two groups according to predisposing factors: the first type correlates with a HPV infection and occurs mostly in younger patients. The second group is not HPV associated and occurs often in elderly women without neoplastic epithelial disorders. Histology: Squamous cell carcinoma (SCC) is the most common malignant tumor of the vulva (95%). Clinical features: Pruritus is the most common and long-lasting reported symptom of vulvar cancer, followed by vulvar bleeding, discharge, dysuria, and pain. Therapy: The gold standard for even a small invasive carcinoma of the vulva was historically radical vulvectomy with removal of the tumor with a wide margin followed by an en bloc resection of the inguinal and often the pelvic lymph nodes. Currently, a more individualized and less radical treatment is suggested: a radical wide local excision is possible in the case of localized lesions (T1). A sentinel lymph node (SLN) biopsy may be performed to reduce wound complications and lymphedema. Prognosis: The survival of patients with vulvar cancer is good when convenient therapy is arranged quickly after initial diagnosis. Inguinal and/or femoral node involvement is the most significant prognostic factor for survival.
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Germany (DE)How to cite
APA:
Alkatout, I., Schubert, M., Garbrecht, N., Weigel, M.T., Jonat, W., Mundhenke, C., & Günther, V. (2015). Vulvar cancer: Epidemiology, clinical presentation, and management options. International Journal of Women's Health , 7, 305-313. https://doi.org/10.2147/IJWH.S68979
MLA:
Alkatout, Ibrahim, et al. "Vulvar cancer: Epidemiology, clinical presentation, and management options." International Journal of Women's Health 7 (2015): 305-313.
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