Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin
Seliger C, Meyer AL, Leidgens V, Rauer L, Moeckel S, Jachnik B, Proske J, Dettmer K, Rothhammer-Hampl T, Kaulen LD, Riemenschneider MJ, Oefner PJ, Kreutz M, Schmidt NO, Merrill M, Uhl M, Renner K, Vollmann-Zwerenz A, Proescholdt M, Hau P (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 23
Article Number: 11629
Journal Issue: 19
Abstract
Brain-tumor-initiating cells (BTICs) of proneural and mesenchymal origin contribute to the highly malignant phenotype of glioblastoma (GB) and resistance to current therapies. BTICs of different subtypes were challenged with oxidative phosphorylation (OXPHOS) inhibition with metformin to assess the differential effects of metabolic intervention on key resistance features. Whereas mesenchymal BTICs varied according to their invasiveness, they were in general more glycolytic and less responsive to metformin. Proneural BTICs were less invasive, catabolized glucose more via the pentose phosphate pathway, and responded better to metformin. Targeting glycolysis may be a promising approach to inhibit tumor cells of mesenchymal origin, whereas proneural cells are more responsive to OXPHOS inhibition. Future clinical trials exploring metabolic interventions should account for metabolic heterogeneity of brain tumors.
Authors with CRIS profile
Involved external institutions
Universitätsklinikum Regensburg
Germany (DE)
Universität Regensburg
Germany (DE)
National Institute of Neurological Disorders and Stroke (NINDS)
United States (USA) (US)
Universitätsklinikum Heidelberg
Germany (DE)
Germany (DE)
Universität Regensburg
Germany (DE)
National Institute of Neurological Disorders and Stroke (NINDS)
United States (USA) (US)
Universitätsklinikum Heidelberg
Germany (DE)
How to cite
APA:
Seliger, C., Meyer, A.-L., Leidgens, V., Rauer, L., Moeckel, S., Jachnik, B.,... Hau, P. (2022). Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin. International Journal of Molecular Sciences, 23(19). https://doi.org/10.3390/ijms231911629
MLA:
Seliger, Corinna, et al. "Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin." International Journal of Molecular Sciences 23.19 (2022).
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