Emerging roles of leptin in Parkinson's disease: Chronic inflammation, neuroprotection and more?

Regensburger M, Rasul Chaudhry S, Yasin H, Zhao Y, Stadlbauer A, Buchfelder M, Kinfe TM (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Book Volume: 107

Pages Range: 53-61

DOI: 10.1016/j.bbi.2022.09.010

Abstract

An increasing body of experimental evidence implicates a relationship between immunometabolic deterioration and the progression of Parkinson's disease (PD) with a dysregulation of central and peripheral neuroinflammatory networks mediated by circulating adipokines, in particular leptin. We screened the current literature on the role of adipokines in PD. Hence, we searched known databases (PubMed, MEDLINE/OVID) and reviewed original and review articles using the following terms: “leptin/ObR”, “Parkinson's disease”, “immune-metabolism”, “biomarkers” and “neuroinflammation”. Focusing on leptin, we summarize and discuss the existing in vivo and in vitro evidence on how adipokines may be protective against neurodegeneration, but at the same time contribute to the progression of PD. These components of the adipose brain axis represent a hitherto underestimated pathway to study systemic influences on dopaminergic degeneration. In addition, we give a comprehensive update on the potential of adjunctive therapeutics in PD targeting leptin, leptin-receptors, and associated pathways. Further experimental and clinical trials are needed to elucidate the mechanisms of action and the value of central and peripheral adipose-immune-metabolism molecular phenotyping in order to develop and validate the differential roles of different adipokines as potential therapeutic target for PD patients.

Authors with CRIS profile

Involved external institutions

Shifa Tameer-e-Millat University Pakistan (PK) Obaid Noor Institute of Medical Sciences (ONIMS) Pakistan (PK)

How to cite

APA:

Regensburger, M., Rasul Chaudhry, S., Yasin, H., Zhao, Y., Stadlbauer, A., Buchfelder, M., & Kinfe, T.M. (2023). Emerging roles of leptin in Parkinson's disease: Chronic inflammation, neuroprotection and more? Brain Behavior and Immunity, 107, 53-61. https://doi.org/10.1016/j.bbi.2022.09.010

MLA:

Regensburger, Martin, et al. "Emerging roles of leptin in Parkinson's disease: Chronic inflammation, neuroprotection and more?" Brain Behavior and Immunity 107 (2023): 53-61.

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