Analysis of HDACi-Coupled Nanoparticles: Opportunities and Challenges

Kühne M, Hofmann S, Lindemann H, Cseresnyés Z, Dzierza A, Schröder D, Godmann M, Koschella A, Eggeling C, Fischer D, Figge MT, Heinze T, Heinzel T (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Methods in Molecular Biology Humana Press

Book Volume: 2589

Pages Range: 129-144

DOI: 10.1007/978-1-0716-2788-4_9

Abstract

Systemic administration of histone deacetylase inhibitors (HDACi), like valproic acid (VPA), is often associated with rapid drug metabolization and untargeted tissue distribution. This requires high-dose application that can lead to unintended side effects. Hence, drug carrier systems such as nanoparticles (NPs) are developed to circumvent these disadvantages by enhancing serum half-life as well as organ specificity.This chapter gives a summary of the biological characterization of HDACi-coupled NPs in vitro, including investigation of cellular uptake, biocompatibility, as well as intracellular drug release and activity. Suitable methods, opportunities, and challenges will be discussed to provide general guidelines for the analysis of HDACi drug carrier systems with a special focus on recently developed cellulose-based VPA-coupled NPs.

Authors with CRIS profile

Andreas Dzierza Lehrstuhl für Pharmazeutische Technologie und Biopharmazie Dagmar Fischer Lehrstuhl für Pharmazeutische Technologie und Biopharmazie

Involved external institutions

Friedrich-Schiller-Universität Jena DE Germany (DE)

How to cite

APA:

Kühne, M., Hofmann, S., Lindemann, H., Cseresnyés, Z., Dzierza, A., Schröder, D.,... Heinzel, T. (2023). Analysis of HDACi-Coupled Nanoparticles: Opportunities and Challenges. Methods in Molecular Biology, 2589, 129-144. https://doi.org/10.1007/978-1-0716-2788-4_9

MLA:

Kühne, Marie, et al. "Analysis of HDACi-Coupled Nanoparticles: Opportunities and Challenges." Methods in Molecular Biology 2589 (2023): 129-144.

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