Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia
Kleineidam L, Wagner M, Guski J, Wolfsgruber S, Miebach L, Bickel H, Koenig HH, Weyerer S, Luehmann D, Kaduszkiewicz H, Luppa M, Rohr S, Pentzek M, Wiese B, Maier W, Scherer M, Kornhuber J, Peters O, Frolich L, Wiltfang J, Lewczuk P, Huell M, Ramirez A, Jessen F, Riedel-Heller SG, Heser K (2022)
Publication Type: Journal article
Publication year: 2022
Journal
DOI: 10.1002/alz.12785
Abstract
Introduction: Subjective cognitive decline (SCD) and depressive symptoms (DS) frequently co-occur prior to dementia. However, the temporal sequence of their emergence and their combined prognostic value for cognitive decline and dementia is unclear. Methods: Temporal relationships of SCD, DS and memory decline were examined by latent difference score modeling in a high-aged, population-based cohort (N = 3217) and validated using Cox-regression of dementia-conversion. In 334 cognitively unimpaired SCD-patients from memory-clinics, we examined the association of DS with cognitive decline and with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Results: In the population-based cohort, SCD preceded DS. High DS were associated with increased risk of dementia conversion in individuals with SCD. In SCD-patients from memory-clinics, high DS were associated with greater cognitive decline. CSF Aß42 predicted increasing DS. Discussion: SCD typically precedes DS in the evolution to dementia. SCD-patients from memory-clinics with DS may constitute a high-risk group for cognitive decline. Highlights: Subjective cognitive decline (SCD) precedes depressive symptoms (DS) as memory declines. Emerging or persistent DS after SCD reports predict dementia. In SCD patients, more amyloid pathology relates to increasing DS. SCD patients with DS are at high risk for symptomatic progression.
Authors with CRIS profile
Johannes Kornhuber
Lehrstuhl für Psychiatrie und Psychotherapie
Piotr Lewczuk
Department of Psychiatry and Psychotherapy
Involved external institutions
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Universität Leipzig
Germany (DE)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Universitätsklinikum Göttingen
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Heinrich-Heine-Universität Düsseldorf
Germany (DE)
Universitätsklinikum Mannheim
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Universität Leipzig
Germany (DE)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Universitätsklinikum Göttingen
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Heinrich-Heine-Universität Düsseldorf
Germany (DE)
Universitätsklinikum Mannheim
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
How to cite
APA:
Kleineidam, L., Wagner, M., Guski, J., Wolfsgruber, S., Miebach, L., Bickel, H.,... Heser, K. (2022). Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia. Alzheimers & Dementia. https://doi.org/10.1002/alz.12785
MLA:
Kleineidam, Luca, et al. "Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia." Alzheimers & Dementia (2022).
BibTeX: Download