Downregulation of the Tumor Suppressor TFF1 Is Required during Induction of Colon Cancer Progression by L1
Saha A, Gavert N, Brabletz T, Ben-Ze'Ev A (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 14
Article Number: 4478
Journal Issue: 18
Abstract
The immunoglobulin family cell adhesion receptor L1 is induced in CRC cells at the invasive front of the tumor tissue, and confers enhanced proliferation, motility, tumorigenesis, and liver metastasis. To identify putative tumor suppressors whose expression is downregulated in L1-expressing CRC cells, we blocked the L1–ezrin–NF-κB signaling pathway and searched for genes induced under these conditions. We found that TFF1, a protein involved in protecting the mucus epithelial layer of the colon, is downregulated in L1-expressing cells and displays characteristics of a tumor suppressor. Overexpression of TFF1 in L1-transfected human CRC cells blocks the pro-tumorigenic and metastatic properties conferred by L1 by suppressing NF-κB signaling. Immunohistochemical analyses revealed that human CRC tissue samples often lose the expression of TFF1, while the normal mucosa displays TFF1 in goblet cells. Identifying TFF1 as a tumor suppressor in CRC cells could provide a novel marker for L1-mediated CRC development and a potential target for therapy.
Authors with CRIS profile
Thomas Brabletz
Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung
Involved external institutions
Israel (IL)How to cite
APA:
Saha, A., Gavert, N., Brabletz, T., & Ben-Ze'Ev, A. (2022). Downregulation of the Tumor Suppressor TFF1 Is Required during Induction of Colon Cancer Progression by L1. Cancers, 14(18). https://doi.org/10.3390/cancers14184478
MLA:
Saha, Arka, et al. "Downregulation of the Tumor Suppressor TFF1 Is Required during Induction of Colon Cancer Progression by L1." Cancers 14.18 (2022).
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