Gibt es eine systemische Muskelschwäche nach intravesikaler Botulinumtoxin-Behandlung? Eine Annäherung an ein uro-geriatrisches Problem
Wiedemann A, Haider S, Heppner HJ (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 51
Pages Range: 48-52
Journal Issue: 1
DOI: 10.1055/a-1069-6967
Abstract
Introduction Muscle weakness after botulinum toxin injection into the detrusor muscle due to refractory overactive bladder is reported by approximately 10% of patients in clinical studies. This could further aggravate the risk of falls in geriatric patients. For the first time, the potential problem of muscle weakness after urologic treatment with botulinum toxin was to be investigated by a geriatric assessment (hand grip measurement). Material und method In a prospective study design, hand grip was measured before and three months after botulinum toxin injection into the urinary bladder in a dose of 100-200MU. The measurement was performed with the usual hand grip device by pressing the pressure gauge three times with the dominant hand. Relevant muscle weakness was assumed if hand grip was reduced by more than 20%. The measurement of 100 patients was intended. Results In an interim analysis of 53 patients with an average age of 65.25±13.99 years, the decrease in hand grip was +0.00±0.06kPa or -0.13±1.69%. In patients receiving 100MU of botulinum toxin, the decrease was +0.01±0.06kPa or -0.29±1.64%; after injection of 200MU, it was 0.02±0.06kPa or 0.720±1.77%. The changes were neither significant for the overall population nor for the differences between the dosage groups. Therefore, the study was terminated. Conclusion The results of the hand grip measurement performed after botulinum toxin injection into the detrusor muscle demonstrated for the first time that there is no loss in hand grip as a possible indicator of muscle weakness and a risk of falls after urologic treatment with 100 MU or 200 MU. Accordingly, the botulinum toxin injection due to refractory overactive bladder seems to be safe for geriatric patients.
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Germany (DE)How to cite
APA:
Wiedemann, A., Haider, S., & Heppner, H.J. (2020). Gibt es eine systemische Muskelschwäche nach intravesikaler Botulinumtoxin-Behandlung? Eine Annäherung an ein uro-geriatrisches Problem. Aktuelle Urologie, 51(1), 48-52. https://doi.org/10.1055/a-1069-6967
MLA:
Wiedemann, Andreas, Shareef Haider, and Hans Jürgen Heppner. "Gibt es eine systemische Muskelschwäche nach intravesikaler Botulinumtoxin-Behandlung? Eine Annäherung an ein uro-geriatrisches Problem." Aktuelle Urologie 51.1 (2020): 48-52.
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