Preoperative PSA levels and development of PSA after 180-W XPS greenlight laser treatment of the prostate: What is the reality in clinical routine practice? Präoperative PSA-Werte und PSA-Verlauf nach 180-Watt-XPS-Greenlight-Laserung der Prostata - wie ist die Realität im klinischen Alltag?
Wiedemann A, Heese M, Heppner HJ (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 51
Pages Range: 53-58
Journal Issue: 1
DOI: 10.1055/a-1021-6776
Abstract
Introduction The aim of this retrospective study was to evaluate preoperative levels of PSA (prostate-specific antigen) and the postoperative development after 180-W XPS™ greenlight laser treatment of the prostate under real-world conditions. Method Preoperative PSA levels were evaluated in 749 patients undergoing a 180-W XPS greenlight laser procedure from 2012 to 2017 in Witten, Germany, in relation to age, volume of the prostate, urinary tract infection, Foley catheter and co-morbidities. The postoperative development of PSA was identified by retrieving PSA levels from general practitioners or urologists. Results The average age of the patients was 73.33±9.26 years. The prostate volume measured by rectal ultrasound was 42.42±18.33ml. Median preoperative PSA was 2.59ng/ml. In 268 patients (35.8%), the PSA level was above 4ng/ml. It was evaluated by prostate biopsy in 106 patients (39.6%). 6 months after the surgical procedure (n=86), PSA decreased to 1.25ng/ml and increased slightly to 1.46ng/ml after 12 months (n=126). Logistic regression analysis demonstrated that a PSA level elevated to more than 4ng/ml preoperatively is related to prostate volume (p=0.001) the existence of a transurethral Foley catheter (p=0.002), but not to age (p=0.349), the existence of a suprapubic catheter (p=0.207), an infection of the lower urinary tract (p=0.966) and the number of co-morbidities mentioned in the discharge letter (p=0.936). Discussion In line with expectations and clinical trials, there was a postoperative decrease of PSA by more than a half of the preoperative value. Significant factors related to preoperative elevation of the PSA level were prostate volume, a transurethral Foley catheter instead of the suprapubic type of catheter and a urinary infection. Although elevated PSA levels were seen in about one third of patients, evaluation by prostate biopsy was only performed in 39.6% of these patients due to their performance status and other clinical issues.
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Wiedemann, A., Heese, M., & Heppner, H.J. (2020). Preoperative PSA levels and development of PSA after 180-W XPS greenlight laser treatment of the prostate: What is the reality in clinical routine practice? Präoperative PSA-Werte und PSA-Verlauf nach 180-Watt-XPS-Greenlight-Laserung der Prostata - wie ist die Realität im klinischen Alltag? Aktuelle Urologie, 51(1), 53-58. https://doi.org/10.1055/a-1021-6776
MLA:
Wiedemann, Andreas, Melanie Heese, and Hans Jürgen Heppner. "Preoperative PSA levels and development of PSA after 180-W XPS greenlight laser treatment of the prostate: What is the reality in clinical routine practice? Präoperative PSA-Werte und PSA-Verlauf nach 180-Watt-XPS-Greenlight-Laserung der Prostata - wie ist die Realität im klinischen Alltag?" Aktuelle Urologie 51.1 (2020): 53-58.
BibTeX: Download