DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment
Bernhardt D, Koenig L, Grosu AL, Rieken S, Krieg SM, Wick W, Wiestler B, Schmidt-Graf F, Sahm F, Gempt J, Meyer B, Krause BJ, Petersen C, Fietkau R, Thomas M, Giordano F, Wittig-Sauerwein A, Debus J, Tabatabai G, Hau P, Steinbach J, Combs SE (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Journal
DOI: 10.1007/s00066-022-01973-8
Abstract
Purpose The Working Group for Neurooncology of the German Society for Radiation Oncology (DEGRO; AG NRO) in cooperation with members of the Neurooncological Working Group of the German Cancer Society (DKG-NOA) aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS). Methods Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN, including bevacizumab, in clinical routine. Conclusion Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neurooncologist. If the diagnosis of blood-brain barrier disruptions (BBD) or RN is likely, treatment should be initiated depending on the symptoms, location, and dynamic of the lesion. Multiple treatment options are available (such as observation, surgery, steroids, and bevacizumab) and the optimal approach should be discussed in an interdisciplinary setting. In this practice guideline, we offer detailed treatment strategies for various scenarios.
Authors with CRIS profile
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
Universitätsklinikum Heidelberg
Germany (DE)
Universitätsklinikum Göttingen
Germany (DE)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
Universitätsmedizin Rostock
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Universitätsklinikum Jena
Germany (DE)
Deutsches Konsortium für Translationale Krebsforschung (DKTK)
Germany (DE)
Eberhard Karls Universität Tübingen
Germany (DE)
Universitätsklinikum Regensburg
Germany (DE)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Germany (DE)
Universitätsklinikum Heidelberg
Germany (DE)
Universitätsklinikum Göttingen
Germany (DE)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
Universitätsmedizin Rostock
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Universitätsklinikum Jena
Germany (DE)
Deutsches Konsortium für Translationale Krebsforschung (DKTK)
Germany (DE)
Eberhard Karls Universität Tübingen
Germany (DE)
Universitätsklinikum Regensburg
Germany (DE)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
How to cite
APA:
Bernhardt, D., Koenig, L., Grosu, A.-L., Rieken, S., Krieg, S.M., Wick, W.,... Combs, S.E. (2022). DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment. Strahlentherapie und Onkologie. https://doi.org/10.1007/s00066-022-01973-8
MLA:
Bernhardt, Denise, et al. "DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment." Strahlentherapie und Onkologie (2022).
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