Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study

Dixon-Suen SC, Lewis SJ, Martin RM, English DR, Boyle T, Giles GG, Michailidou K, Bolla MK, Wang Q, Dennis J, Lush M, Ahearn TU, Ambrosone CB, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Augustinsson A, Auvinen P, Beane Freeman LE, Becher H, Beckmann M, Behrens S, Bermisheva M, Blomqvist C, Bogdanova N, Bojesen SE, Bonanni B, Brenner H, Bruening T, Buys SS, Camp NJ, Campa D, Canzian F, Castelao JE, Cessna MH, Chang-Claude J, Chanock SJ, Clarke CL, Conroy DM, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Doerk T, Dwek M, Eccles DM, Eliassen AH, Engel C, Eriksson M, Evans DG, Fasching P, Fletcher O, Flyger H, Fritschi L, Gabrielson M, Gago-Dominguez M, Garcia-Closas M, Garcia-Saenz JA, Goldberg MS, Guenel P, Guendert M, Hahnen E, Haiman CA, Häberle L, Hakansson N, Hall P, Hamann U, Hart SN, Harvie M, Hillemanns P, Hollestelle A, Hooning MJ, Hoppe R, Hopper J, Howell A, Hunter DJ, Jakubowska A, Janni W, John EM, Jung A, Kaaks R, Keeman R, Kitahara CM, Koutros S, Kraft P, Kristensen VN, Kubelka-Sabit K, Kurian AW, Lacey J, Lambrechts D, Le Marchand L, Lindblom A, Loibl S, Lubinski J, Mannermaa A, Manoochehri M, Margolin S, Martinez ME, Mavroudis D, Menon U, Mulligan AM, Murphy RA, Nevanlinna H, Nevelsteen I, Newman WG, Offit K, Olshan AF, Olsson H, Orr N, Patel A, Peto J, Plaseska-Karanfilska D, Presneau N, Rack B, Radice P, Rees-Punia E, Rennert G, Rennert HS, Romero A, Saloustros E, Sandler DP, Schmidt MK, Schmutzler RK, Schwentner L, Scott C, Shah M, Shu XO, Simard J, Southey MC, Stone J, Surowy H, Swerdlow AJ, Tamimi RM, Tapper WJ, Taylor JA, Terry MB, Tollenaar RAEM, Troester MA, Truong T, Untch M, Vachon CM, Joseph V, Wappenschmidt B, Weinberg CR, Wolk A, Yannoukakos D, Zheng W, Ziogas A, Dunning AM, Pharoah PDP, Easton DF, Milne RL, Lynch BM (2022)

Publication Type: Journal article

Publication year: 2022

Journal

DOI: 10.1136/bjsports-2021-105132

Abstract

Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.

Authors with CRIS profile

Involved external institutions

University of South Australia Australia (AU) Lund University / Lunds universitet Sweden (SE) National Institute of Environmental Health Sciences (NIEHS) United States (USA) (US) Russian Academy of Sciences / Росси́йская акаде́мия нау́к (RAS) Russian Federation (RU) HELIOS Kliniken Germany (DE) Karolinska Institute Sweden (SE) Cancer Council Victoria Australia (AU) University of Bristol United Kingdom (GB) National Cancer Institute (NCI) United States (USA) (US) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) University of Southampton United Kingdom (GB) University of Cambridge United Kingdom (GB) University of North Carolina at Chapel Hill United States (USA) (US) University of Utah United States (USA) (US) Roswell Park Cancer Institute United States (USA) (US) Cyprus Institute of Neurology and Genetics Cyprus (CY) Kuopio University Hospital / Pohjois-Savon sairaanhoitopiiri Finland (FI) Copenhagen University Hospital Denmark (DK) Helsingin yliopisto / University of Helsinki Finland (FI) Queen's University United Kingdom (GB) École Polytechnique - Université Paris-Saclay France (FR) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Intermountain Healthcare United States (USA) (US) University of Sheffield United Kingdom (GB) The Institute of Cancer Research (ICR) United Kingdom (GB) Leiden University Netherlands (NL) Brigham and Women's Hospital (BWH) United States (USA) (US) Fox Chase Cancer Center United States (USA) (US) Universität Leipzig Germany (DE) Hospital Clínico San Carlos Spain (ES) University of Eastern Finland Finland (FI) University of Manchester United Kingdom (GB) Erasmus University Medical Center (MC) Netherlands (NL) Robert-Bosch-Krankenhaus Germany (DE) Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB) Belgium (BE) Acibadem Sistina Hospital Republic of North Macedonia (MK) Mayo Clinic United States (USA) (US) McGill University Canada (CA) The University of Melbourne Australia (AU) Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) Stanford University United States (USA) (US) Memorial Sloan Kettering Cancer Center United States (USA) (US) University General Hospital of Heraklion Greece (GR) Universität zu Köln Germany (DE) American Cancer Society United States (USA) (US) Fondazione IRCCS: Istituto Nazionale dei Tumori Italy (IT) Clalit Health Services Israel (IL) General University Hospital of Larissa Greece (GR) BC Cancer Canada (CA) GBG Forschungs GmbH (German Breast Group) Germany (DE) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI / NKI-AVL) Netherlands (NL) University College London (UCL) United Kingdom (GB) Universitätsklinikum Ulm Germany (DE) University of Toronto Canada (CA) Université Laval (UL) Canada (CA) Harvard University United States (USA) (US) Vanderbilt University United States (USA) (US) University of California Irvine United States (USA) (US) University of Westminster United Kingdom (GB) Complejo Hospitalario Universitario de Santiago de Compostela Spain (ES) Södersjukhuset Sweden (SE) National Centre for Scientific Research (NCSR) "Demokritos" Greece (GR) Ruhr-Universität Bochum (RUB) Germany (DE) City of Hope Medical Center United States (USA) (US) University of California, San Diego (UC San Diego, UCSD) United States (USA) (US) University of Sydney (USYD) Australia (AU) London School of Hygiene and Tropical Medicine United Kingdom (GB) Hospital Universitario Puerta de Hierro - Majadahonda Spain (ES) Mount Sinai Hospital (MSH) Canada (CA) Manchester University NHS Foundation Trust (MFT) United Kingdom (GB) European Institute of Oncology / Istituto Europeo di Oncologia (IEO) Italy (IT) University of Hawaii (U.H.) United States (USA) (US) Columbia University United States (USA) (US) University of Southern California (USC) United States (USA) (US) Curtin University Australia (AU) Instituto de Investigación Sanitaria Galicia Sur Spain (ES)

How to cite

APA:

Dixon-Suen, S.C., Lewis, S.J., Martin, R.M., English, D.R., Boyle, T., Giles, G.G.,... Lynch, B.M. (2022). Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study. British Journal of Sports Medicine. https://doi.org/10.1136/bjsports-2021-105132

MLA:

Dixon-Suen, Suzanne C., et al. "Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study." British Journal of Sports Medicine (2022).

BibTeX: Download