Choi JY, Hu S, Su TY, Murakami H, Tang Y, Blümcke I, Najm I, Sakaie K, Jones S, Griswold M, Wang ZI, Ma D (2022)
Publication Language: English
Publication Type: Journal article
Publication year: 2022
Book Volume: 33
Pages Range: 3562-3574
Journal Issue: 7
Quantitative magnetic resonance (MR) has been used to study cyto- and myelo-architecture of the human brain non-invasively. However, analyzing brain cortex using high-resolution quantitative MR acquisition can be challenging to perform using 3T clinical scanners. MR fingerprinting (MRF) is a highly efficient and clinically feasible quantitative MR technique that simultaneously provides T-1 and T-2 relaxation maps. Using 3D MRF from 40 healthy subjects (mean age = 25.6 +/- 4.3 years) scanned on 3T magnetic resonance imaging, we generated whole-brain gyral-based normative MR relaxation atlases and investigated cortical-region-based T-1 and T-2 variations. Gender and age dependency of T-1 and T-2 variations were additionally analyzed. The coefficient of variation of T-1 and T-2 for each cortical-region was 3.5% and 7.3%, respectively, supporting low variability of MRF measurements across subjects. Significant differences in T-1 and T-2 were identified among 34 brain regions (P < 0.001), lower in the precentral, postcentral, paracentral lobule, transverse temporal, lateral occipital, and cingulate areas, which contain sensorimotor, auditory, visual, and limbic functions. Significant correlations were identified between age and T-1 and T-2 values. This study established whole-brain MRF T-1 and T-2 atlases of healthy subjects using a clinical 3T scanner, which can provide a quantitative and region-specific baseline for future brain studies and pathology detection.
APA:
Choi, J.Y., Hu, S., Su, T.-Y., Murakami, H., Tang, Y., Blümcke, I.,... Ma, D. (2022). Normative quantitative relaxation atlases for characterization of cortical regions using magnetic resonance fingerprinting. Cerebral Cortex, 33(7), 3562-3574. https://doi.org/10.1093/cercor/bhac292
MLA:
Choi, Joon Yul, et al. "Normative quantitative relaxation atlases for characterization of cortical regions using magnetic resonance fingerprinting." Cerebral Cortex 33.7 (2022): 3562-3574.
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