Prasuhn J, Göttlich M, Grosser SS, Reuther K, Ebeling B, Bodemann C, Hanssen H, Nagel AM, Brüggemann N (2022)
Publication Type: Journal article
Publication year: 2022
Book Volume: 10
Journal Issue: 7
DOI: 10.3390/biomedicines10071728
Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (Na-23-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) Na-23-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. Na-23-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.
APA:
Prasuhn, J., Göttlich, M., Grosser, S.S., Reuther, K., Ebeling, B., Bodemann, C.,... Brüggemann, N. (2022). Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy. Biomedicines, 10(7). https://doi.org/10.3390/biomedicines10071728
MLA:
Prasuhn, Jannik, et al. "Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy." Biomedicines 10.7 (2022).
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