On contrast mechanisms in p-space imaging
Straub S, Ladd ME, Wetscherek A, Laun FB (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 75
Pages Range: 2526-2533
Journal Issue: 6
DOI: 10.1002/mrm.25812
Abstract
Purpose The effects of microstructure on susceptibility mapping have recently received increasing attention. In this work, the capability of p-space imaging to resolve subvoxel structure and susceptibility is assessed. Methods In a simulation study, the p-space contrast of axon bundles comprised of hollow cylinders is investigated. Various axon and susceptibility distributions are considered and compared with the corresponding case of a voxel with homogeneous substructure of the order of the voxel size. Results MR signal behavior for p-space imaging of a voxel containing axon bundles and a voxel containing homogeneous substructure are nearly identical. Conclusion p-Space imaging resolves subvoxel structure of the order of the voxel size. Due to dephasing effects, strong susceptibility variations alter p-space contrast. However, p-space contrast is not directly linked to the susceptibility of the axon compartment.
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Straub, S., Ladd, M.E., Wetscherek, A., & Laun, F.B. (2016). On contrast mechanisms in p-space imaging. Magnetic Resonance in Medicine, 75(6), 2526-2533. https://doi.org/10.1002/mrm.25812
MLA:
Straub, Sina, et al. "On contrast mechanisms in p-space imaging." Magnetic Resonance in Medicine 75.6 (2016): 2526-2533.
BibTeX: Download