Characterization and therapy monitoring of head and neck carcinomas using diffusion-imaging-based intravoxel incoherent motion parameters - Preliminary results

Hauser T, Essig M, Jensen A, Gerigk L, Laun FB, Muenter M, Simon D, Stieltjes B (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Neuroradiology Springer Verlag (Germany)

Book Volume: 55

Pages Range: 527-536

Journal Issue: 5

DOI: 10.1007/s00234-013-1154-9

Abstract

Introduction: Using the intravoxel incoherent motion (IVIM) model, diffusion-related coefficient (D) and perfusion-related parameter (f) can be measured. Here, we used IVIM imaging to characterize squamous cell carcinomas of head and neck (HNSCC) and evaluated its application in follow-up after nonsurgical organ preserving therapy. Methods: Twenty-two patients with locally advanced HNSCC (clinical stage III to IVb) were examined before treatment using eight different b values (b = 0, 50, 100, 150, 200, 250, 700, 800 s/mm ²). All patients were followed for at least 7.5 months after conclusion of therapy. In 16 of these patients, follow-up MRI was available. Using the IVIM approach, f and D were extracted using a bi-exponential fit. For comparison, ADC maps were calculated. Results: The initial values of f before therapy were located between 5.9 % and 12.9 % (mean: 9.4 ± 2.4 %) except for two outliers (f = 17.9 % and 18.2 %). These two patients exclusively displayed poor initial treatment response. Overall, high initial f (13.1 ± 4.1 % vs. 9.1 ± 2.4 %) and ADC (1.17 ± 0.08 × 10^-3 mm²/s vs. 0.98 ± 0.19 × 10^-3 mm²/s) were associated with poor short term outcome (n = 6) after 7.5 months follow-up. D values before treatment were 0.98 × 10^-3 ± 0.18 mm²/s and ADC values were 1.03 × 10^-3 ± 0.18 mm²/s. At follow-up, in all primary responders, D (69 ± 52 %), f (65 ± 46 %), and ADC (68 ± 49%) increased. Conclusions: Our preliminary evaluation indicates that an initial high f may predict poor prognosis in HNSCC. In responders, a significant increase of all IVIM parameters after therapy was demonstrated. © 2013 Springer-Verlag Berlin Heidelberg.

Authors with CRIS profile

Frederik Bernd Laun

Involved external institutions

Deutsches Krebsforschungszentrum (DKFZ)

Germany (DE) Ruprecht-Karls-Universität Heidelberg

Germany (DE)

How to cite

APA:

Hauser, T., Essig, M., Jensen, A., Gerigk, L., Laun, F.B., Muenter, M.,... Stieltjes, B. (2013). Characterization and therapy monitoring of head and neck carcinomas using diffusion-imaging-based intravoxel incoherent motion parameters - Preliminary results. Neuroradiology, 55(5), 527-536. https://doi.org/10.1007/s00234-013-1154-9

MLA:

Hauser, Thomas, et al. "Characterization and therapy monitoring of head and neck carcinomas using diffusion-imaging-based intravoxel incoherent motion parameters - Preliminary results." Neuroradiology 55.5 (2013): 527-536.

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