Neural ECM proteases in learning and synaptic plasticity
Tsilibary E, Tzinia A, Radenovic L, Stamenkovic V, Lebitko T, Mucha M, Pawlak R, Frischknecht R, Kaczmarek L (2014)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2014
Journal
Publisher: Elsevier B.V.
Series: Progress in Brain Research
Book Volume: 214
Pages Range: 135-157
DOI: 10.1016/B978-0-444-63486-3.00006-2
Abstract
Recent studies implicate extracellular proteases in synaptic plasticity, learning, and memory. The data are especially strong for such serine proteases as thrombin, tissue plasminogen activator, neurotrypsin, and neuropsin as well as matrix metalloproteinases, MMP-9 in particular. The role of those enzymes in the aforementioned phenomena is supported by the experimental results on the expression patterns (at the gene expression and protein and enzymatic activity levels) and functional studies, including knockout mice, specific inhibitors, etc. Counterintuitively, the studies have shown that the extracellular proteolysis is not responsible mainly for an overall degradation of the extracellular matrix (ECM) and loosening perisynaptic structures, but rather allows for releasing signaling molecules from the ECM, transsynaptic proteins, and latent form of growth factors. Notably, there are also indications implying those enzymes in the major neuropsychiatric disorders, probably by contributing to synaptic aberrations underlying such diseases as schizophrenia, bipolar, autism spectrum disorders, and drug addiction.
Involved external institutions
National Centre for Scientific Research (NCSR) "Demokritos"
Greece (GR)
University of Belgrade / Универзитет у Београду
Serbia (RS)
Nencki Institute of Experimental Biology / Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
Poland (PL)
University of Exeter
United Kingdom (GB)
Max-Planck-Institut für Neurobiologie / Max Planck Institute of Neurobiology
Germany (DE)
Greece (GR)
University of Belgrade / Универзитет у Београду
Serbia (RS)
Nencki Institute of Experimental Biology / Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
Poland (PL)
University of Exeter
United Kingdom (GB)
Max-Planck-Institut für Neurobiologie / Max Planck Institute of Neurobiology
Germany (DE)
How to cite
APA:
Tsilibary, E., Tzinia, A., Radenovic, L., Stamenkovic, V., Lebitko, T., Mucha, M.,... Kaczmarek, L. (2014). Neural ECM proteases in learning and synaptic plasticity. In (pp. 135-157). Elsevier B.V..
MLA:
Tsilibary, Effie, et al. "Neural ECM proteases in learning and synaptic plasticity." Elsevier B.V., 2014. 135-157.
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