Brevican: A key proteoglycan in the perisynaptic extracellular matrix of the brain
Frischknecht R, Seidenbecher CI (2012)
Publication Type: Journal article
Publication year: 2012
Journal
Book Volume: 44
Pages Range: 1051-1054
Journal Issue: 7
DOI: 10.1016/j.biocel.2012.03.022
Abstract
Brevican is a neural proteoglycan implicated in a multitude of physiological and pathophysiological plasticity processes in the brain. It localizes to neuronal surfaces and contributes to the formation of specific types of extracellular matrix like the perineuronal nets or the perisynaptic or axon initial segment-based matrix in mature neuronal tissue. Via a variable degree of chondroitin sulfate attachment, limited proteolytic cleavage by matrix metalloproteinases, differential splicing and Ca2+-dependent binding to interaction partners it acts as a regulator in synaptic plasticity, glioma invasion, post-lesion plasticity or Alzheimer's disease. This review briefly summarizes its gene and protein structure, biochemical interactions and neurobiological functions. © 2012 Elsevier Ltd.
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Germany (DE)How to cite
APA:
Frischknecht, R., & Seidenbecher, C.I. (2012). Brevican: A key proteoglycan in the perisynaptic extracellular matrix of the brain. International Journal of Biochemistry and Cell Biology, 44(7), 1051-1054. https://dx.doi.org/10.1016/j.biocel.2012.03.022
MLA:
Frischknecht, Renato, and Constanze I. Seidenbecher. "Brevican: A key proteoglycan in the perisynaptic extracellular matrix of the brain." International Journal of Biochemistry and Cell Biology 44.7 (2012): 1051-1054.
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