Frischknecht R, Gundelfinger ED (2012)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2012
Edited Volumes: Synaptic Plasticity: Dynamics, Development and Disease
Series: Advances in Experimental Medicine and Biology
Book Volume: 970
Pages Range: 153-171
DOI: 10.1007/978-3-7091-0932-8_7
The extracellular matrix (ECM) of the brain has important roles in regulating synaptic function and plasticity. A juvenile ECM supports the wiring of neuronal networks, synaptogenesis, and synaptic maturation. The closure of critical periods for experience-dependent shaping of neuronal circuits coincides with the implementation of a mature form of ECM that is characterized by highly elaborate hyaluronan-based structures, the perineuronal nets (PNN), and PNN-like perisynaptic ECM specializations. In this chapter, we will focus on some recently reported aspects of ECM functions in brain plasticity. These include (a) the discovery that the ECM can act as a passive diffusion barrier for cell surface molecules including neurotransmitter receptors and in this way compartmentalize cell surfaces, (b) the specific functions of ECM components in actively regulating synaptic plasticity and homeostasis, and (c) the shaping processes of the ECM by extracellular proteases and in turn the activation particular signaling pathways. © 2012 Springer-Verlag/WIen.
APA:
Frischknecht, R., & Gundelfinger, E.D. (2012). The brain's extracellular matrix and its role in synaptic plasticity. In Michael Kreutz, Carlo Sala (Eds.), Synaptic Plasticity: Dynamics, Development and Disease. (pp. 153-171).
MLA:
Frischknecht, Renato, and Eckart D. Gundelfinger. "The brain's extracellular matrix and its role in synaptic plasticity." Synaptic Plasticity: Dynamics, Development and Disease. Ed. Michael Kreutz, Carlo Sala, 2012. 153-171.
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