Cooling in intracerebral hemorrhage (CINCH) trial: Protocol of a randomized German-Austrian clinical trial

Kollmar R, Juettler E, Huttner H, Dörfler A, Staykov D, Kallmünzer B, Schmutzhard E, Schwab S, Broessner G (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Book Volume: 7

Pages Range: 168-172

Journal Issue: 2

DOI: 10.1111/j.1747-4949.2011.00707.x

Abstract

Background: Intracerebral hemorrhage accounts for up to 15% of all strokes and is frequently associated with poor functional outcome and high mortality. So far, there is no clear evidence for a specific therapy, apart from general stroke unit or neurointensive care and management of secondary complications. Promising experimental and pilot clinical data support the use of therapeutic hypothermia after intracerebral hemorrhage. Aims: The study aims to determine if therapeutic hypothermia improves survival rates and reduces cerebral lesion volume after large intracerebral hemorrhage compared with conventional treatment. Material and methods: The Cooling in IntraCerebral Hemorrhage trial is a prospective, multicenter, interventional, randomized, parallel, two-arm (1:1) phase II trial with blinded end-point adjudication. Enrolment: 50 patients (age: 18 to 65 years) with large (25 to 64ml on cranial computertomography), primary intracerebral hemorrhage of the basal ganglia or thalamus within 6 to 18h after symptom onset are randomly allocated to therapeutic hypothermia for eight-days or conventional temperature management. In the therapeutic hypothermia group, a target temperature of 35·0°C is achieved by endovascular catheters and followed by slow controlled rewarming. Data analysis is based on the intent-to-treat population. The primary outcome measure of the study is the development in total lesion volume on cranial computertomography (intracerebral hemorrhage plus perihemorrhagic edema on day 8±0·5 and day 11±0·5 after intracerebral hemorrhage) and the mortality after 30 days. Secondary end-points are the in-hospital mortality, mortality, and functional outcome (modified Rankin Scale and Barthel-Index) after 90 and 180 days. Safety measures include any adverse events associated with therapeutic hypothermia. Discussion: In the face of a lack of evidence-based therapies for patients with large intracerebral hemorrhage, new promising approaches are desperately needed, but need evaluation in randomized controlled trials. Conclusion: The results of Cooling in IntraCerebral Hemorrhage trial are believed to directly influence future therapy of large intracerebral hemorrhage. © 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization.

Authors with CRIS profile

Involved external institutions

Charité - Universitätsmedizin Berlin Germany (DE) Medizinische Universität Innsbruck Austria (AT)

How to cite

APA:

Kollmar, R., Juettler, E., Huttner, H., Dörfler, A., Staykov, D., Kallmünzer, B.,... Broessner, G. (2012). Cooling in intracerebral hemorrhage (CINCH) trial: Protocol of a randomized German-Austrian clinical trial. International Journal of Stroke, 7(2), 168-172. https://doi.org/10.1111/j.1747-4949.2011.00707.x

MLA:

Kollmar, Rainer, et al. "Cooling in intracerebral hemorrhage (CINCH) trial: Protocol of a randomized German-Austrian clinical trial." International Journal of Stroke 7.2 (2012): 168-172.

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