Wagner I, Volbers B, Hilz MJ, Schwab S, Staykov D, Dörfler A (2012)
Publication Type: Journal article
Publication year: 2012
Book Volume: 19
Pages Range: 525-528
Journal Issue: 3
DOI: 10.1111/j.1468-1331.2011.03526.x
Background: Experimental evidence indicates that iron plays a key role in edema formation after intracerebral hemorrhage (ICH). We investigated the relationship between ICH radiopacity on CT as a marker of hematoma iron content and perihemorrhagic edema (PHE) after ICH. Methods: We retrospectively investigated patients with spontaneous lobar and ganglionic supratentorial ICH who received follow-up CT scans during the first 7days after symptom onset (d1, d2-4, d5-7). Measurements of ICH and edema volumes were taken using a semiautomatic threshold-based volumetric algorithm. Radiopacity of the blood clot was determined using the mean Hounsfield unit (HU) count of the ICH. Results: A total of 117 patients aged 71.92±11.55years with spontaneous ICH (34.63±32.44ml) were included in the analysis. Mean ICH radiopacity was 59.7±3.4HU. We found significantly larger relative PHE at d2-4 (1.7±0.9 vs. 1.3±0.8; P=0.032) and d5-7 (2.0±1.3 vs. 1.3±0.9; P=0.007) and larger peak relative PHE (2.3±1.6 vs. 1.6±1.1; P=0.006) in patients with ICH radiopacity >60HU (n=59), as compared to patients with ICH radiopacity <60HU (n=58). Conclusions: Higher ICH radiopacity, reflecting higher in vivo hematoma iron content, is associated with more PHE after ICH. © 2011 The Author(s). European Journal of Neurology © 2011 EFNS.
APA:
Wagner, I., Volbers, B., Hilz, M.-J., Schwab, S., Staykov, D., & Dörfler, A. (2012). Radiopacity of intracerebral hemorrhage correlates with perihemorrhagic edema. European Journal of Neurology, 19(3), 525-528. https://doi.org/10.1111/j.1468-1331.2011.03526.x
MLA:
Wagner, Irina, et al. "Radiopacity of intracerebral hemorrhage correlates with perihemorrhagic edema." European Journal of Neurology 19.3 (2012): 525-528.
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