Differences in metabolism of fiber tract alterations in gliomas: A combined fiber density mapping and magnetic resonance spectroscopic imaging study

Stadlbauer A, Hammen T, Buchfelder M, Bachmair J, Dörfler A, Nimsky C, Ganslandt O (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Neurosurgery Oxford University Press (OUP)

Book Volume: 71

Pages Range: 454-463

Journal Issue: 2

DOI: 10.1227/NEU.0b013e318258e332

Abstract

BACKGROUND: Gliomas propagate diffusely throughout and along white matter structures. Glioma-related changes in structural integrity and metabolism are not detectable by standard magnetic resonance (MR) imaging. OBJECTIVE: To investigate differences in the metabolism of fiber tract alterations between gliomas grade II to IV by correlation of fiber density values with metabolite concentrations measured by fiber density mapping and MR spectroscopic imaging. METHODS: Fiber density mapping and MR spectroscopic imaging were performed in 48 patients with gliomas WHO grade II to IV. Fiber density mapping data were used to define fiber tracts in tumoral and peritumoral areas. Structural integrity of fiber tracts was assessed as fiber density ipsilateral-to-contralateral ratio (FD ICR). Metabolite concentrations for choline-containing compounds and N-acetyl-aspartate were computed and correlated to FD ICR values after coregistration with anatomic MR imaging. RESULTS: In tumoral areas, choline-containing compound concentrations of altered fiber tracts were significantly different between low- and high-grade glioma and showed different courses for the correlations of FD ICR and choline-containing czeompounds. In high-grade glioma, increasing fiber destruction was associated with a massive progression in cell membrane proliferation. Peritumoral fiber structures showed significantly decreased N-acetyl-aspartate concentrations for all patients, but only patients with glioblastoma multiforme had significantly decreased fiber density compared with the contralateral side. Glioma grades II and III had significantly higher peritumoral FD ICR than glioblastoma multiforme. CONCLUSION: A multiparametric MR imaging strategy providing information about both structural integrity and metabolism of the tumor is required for detailed assessment of glioma-related fiber tract alterations, which in turn is essential for treatment planning. Copyright © 2012 by the Congress of Neurological Surgeons.

Authors with CRIS profile

Andreas Stadlbauer Department of Neurosurgery Thilo Hammen Medizinische Fakultät Michael Buchfelder Lehrstuhl für Neurochirurgie Arnd Dörfler Department of Neuroradiology Oliver Thomas Ganslandt Lehrstuhl für Neurochirurgie

Involved external institutions

Landesklinikum St. Pölten AT Austria (AT) Philipps-Universität Marburg DE Germany (DE)

How to cite

APA:

Stadlbauer, A., Hammen, T., Buchfelder, M., Bachmair, J., Dörfler, A., Nimsky, C., & Ganslandt, O. (2012). Differences in metabolism of fiber tract alterations in gliomas: A combined fiber density mapping and magnetic resonance spectroscopic imaging study. Neurosurgery, 71(2), 454-463. https://doi.org/10.1227/NEU.0b013e318258e332

MLA:

Stadlbauer, Andreas, et al. "Differences in metabolism of fiber tract alterations in gliomas: A combined fiber density mapping and magnetic resonance spectroscopic imaging study." Neurosurgery 71.2 (2012): 454-463.

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