MiRNAs in malignant melanoma

Mione M, Liebig J, Munoz L, Boßerhoff AK (2017)

Publication Type: Authored book

Publication year: 2017

Publisher: Springer International Publishing

ISBN: 9783319413198

Abstract

MicroRNAs (miRNAs) represent a class of small noncoding RNAs, first described in the nematode Caenorhabditis elegans. In 1993, the labs of Victor Ambros (Lee et al. Cell 75:843-854, 1993) and Gary Ruvkun (Wightman et al. Cell 75:855-862, 1993) discovered lin-4, the first member of the inexorably growing family of miRNAs. Interestingly, it was not until the year 2000 that Reinhart and colleagues detected a second miRNA species-let-7 (Reinhart et al. Nature 2000;403:901-906). The finding that the sequence of let-7 was conserved in a large variety of Metazoens from Drosophila to humans (in contrast to lin-4, which is exclusively expressed in Caenorhabditis; Pasquinelli et al. Nature 408:86-89, 2000; Slack et al. Mol Cell 2000;5:659-669, 2000) fueled miRNA research and revealed that this class of molecules is involved in the regulation of gene expression at a posttranscriptional level in presumably every multicellular organism. To date, more than 1800 distinct miRNA species have been identified in the human genome (www.miRNA.org Kozomara and Griffiths-Jones 42(Database issue):D68-73, 2014). Those are estimated to regulate the expression of as much as 60 % of all human transcripts (Friedman et al. Genome Res 2009;19:92-105, 2009). MiRNAs are demonstrably involved in the physiological regulation of multiple cellular processes, such as proliferation, apoptosis, and differentiation. As a consequence, abnormalities in miRNA activity were found to contribute to the pathogenesis and progression of various types of human cancers (reviewed by Mirnezami et al. Eur J Surg Oncol 35:339-347, 2009; Visone and Croce Am J Pathol 2009;174:1131-1138, 2009), including malignant melanoma (reviewed by Mione and Bosserhoff Pigment Cell Melanoma Res 2015;28:340-354).

Authors with CRIS profile

Janika Liebig Lehrstuhl für Biochemie und Molekulare Medizin Anja Katrin Boßerhoff Lehrstuhl für Biochemie und Molekulare Medizin

Involved external institutions

Karlsruhe Institute of Technology (KIT)

Germany (DE)

How to cite

APA:

Mione, M., Liebig, J., Munoz, L., & Boßerhoff, A.K. (2017). MiRNAs in malignant melanoma. Springer International Publishing.

MLA:

Mione, Maria, et al. MiRNAs in malignant melanoma. Springer International Publishing, 2017.

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