MicroRNAs in malignant melanoma
Voeller D, Ott C, Bosserhoff A (2013)
Publication Type: Journal article, Review article
Publication year: 2013
Journal
Book Volume: 46
Pages Range: 909-917
Journal Issue: 10-11
DOI: 10.1016/j.clinbiochem.2013.01.008
Abstract
Melanoma is the most aggressive form of skin cancer, and the incidence of melanoma has been increasing faster than that of most other cancers. While the survival rate following surgical resection of early-stage primary tumors is nearly 100%, the survival of patients with metastasized tumors is strongly reduced, likely due to resistance to conventional therapies. Therefore, it is important to use new molecular approaches to develop new biomarkers to better prevent and diagnose melanoma. MicroRNAs (miRNAs) are short non-coding RNAs that post-transcriptionally regulate gene expression via repression of translation or direct degradation of their complementary mRNA. In this review, we summarize our current understanding of the involvement of miRNAs and their corresponding targets in melanomagenesis as well as the potential use of miRNAs as biomarkers. © 2013 The Canadian Society of Clinical Chemists.
Involved external institutions
Germany (DE)How to cite
APA:
Voeller, D., Ott, C., & Bosserhoff, A. (2013). MicroRNAs in malignant melanoma. Clinical Biochemistry, 46(10-11), 909-917. https://doi.org/10.1016/j.clinbiochem.2013.01.008
MLA:
Voeller, Daniel, Corinna Ott, and Anja Bosserhoff. "MicroRNAs in malignant melanoma." Clinical Biochemistry 46.10-11 (2013): 909-917.
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