The ILAE classification of focal cortical dysplasia in clinical routine Die ILAE-Klassifikation fokaler kortikaler Dysplasien im klinischen Gebrauch
Blümcke I, Kobow K, Holthausen H (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 30
Pages Range: 200-207
Journal Issue: 3
DOI: 10.1007/s10309-017-0119-0
Abstract
We would like to discuss the benefits as well as ongoing challenges of the International League Against Epilepsy (ILAE) first consensus classification of focal cortical dysplasia (FCD) published in 2011. FCD is a frequent cause of early onset and drug-resistant focal epilepsy. Success of neurosurgical therapy, however, largely depends on the clinico-pathological subtype, which has been classified into three major subtypes: FCD type 1 is a rare disease frequently observed in young children and is a radiologically, electroclinically and histopathologically difficult to diagnose epilepsy. Post-surgical seizure control is less successful compared to FCD type 2A or FCD type 2B. These FCD type 2 variants are radiologically, electroclinically and histopathologically well described and probably share molecular mutations with other mTORopathies, such as hemimegalencephaly and tuberous sclerosis complex. FCD type 3 is associated with other principal lesions, such as hippocampal sclerosis (FCD 3A), epilepsy-associated tumors (FCD 3B), vascular malformations (FCD 3C) and other lesions acquired during early life (FCD 3D). The pathomechanism remains to be elucidated and success of surgical therapy is often similar to that of the principal lesions rather than being a distinct feature. An up-coming revision of the ILAE classification is currently under discussion to cover progress in molecular diagnostics (as shown in other medical disciplines, please refer to the tumor chapter of this issue); however, major changes in the three-tiered classification scheme are not expected.
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APA:
Blümcke, I., Kobow, K., & Holthausen, H. (2017). The ILAE classification of focal cortical dysplasia in clinical routine Die ILAE-Klassifikation fokaler kortikaler Dysplasien im klinischen Gebrauch. Zeitschrift für Epileptologie, 30(3), 200-207. https://doi.org/10.1007/s10309-017-0119-0
MLA:
Blümcke, Ingmar, Katja Kobow, and Hans Holthausen. "The ILAE classification of focal cortical dysplasia in clinical routine Die ILAE-Klassifikation fokaler kortikaler Dysplasien im klinischen Gebrauch." Zeitschrift für Epileptologie 30.3 (2017): 200-207.
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