RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

Guillen-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schluessler R, Kim K, Trussina IREA, Wang J, Mateju D, Poser I, Maharana S, Ruer-Gruss M, Richter D, Zhang X, Chang YT, Guck J, Honigmann A, Mahamid J, Hyman AA, Pappu RV, Alberti S, Franzmann TM (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Cell Elsevier

Book Volume: 181

Pages Range: 346-361.e17

Journal Issue: 2

DOI: 10.1016/j.cell.2020.03.049

Abstract

Reconstitution of stress granule assembly reveals an autoinhibitory conformation of G3BP that is alleviated by RNA binding, demonstrating how this central node of the stress granule network phase-separates in response to rising cellular RNA concentrations.

Authors with CRIS profile

Jochen Guck

Involved external institutions

Technische Universität Dresden DE Germany (DE) Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) DE Germany (DE) Washington University in St. Louis US United States (USA) (US) European Molecular Biology Laboratory (EMBL) DE Germany (DE) Institute for Basic Science KR Korea, Republic of (KR)

How to cite

APA:

Guillen-Boixet, J., Kopach, A., Holehouse, A.S., Wittmann, S., Jahnel, M., Schluessler, R.,... Franzmann, T.M. (2020). RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation. Cell, 181(2), 346-361.e17. https://doi.org/10.1016/j.cell.2020.03.049

MLA:

Guillen-Boixet, Jordina, et al. "RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation." Cell 181.2 (2020): 346-361.e17.

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