Coupling of active motion and advection shapes intracellular cargo transport
Trong PK, Guck J, Goldstein RE (2012)
Publication Type: Journal article
Publication year: 2012
Journal
Book Volume: 109
Article Number: 028104
Journal Issue: 2
DOI: 10.1103/PhysRevLett.109.028104
Abstract
Intracellular cargo transport can arise from passive diffusion, active motor-driven transport along cytoskeletal filament networks, and passive advection by fluid flows entrained by such cargo-motor motion. Active and advective transport are thus intrinsically coupled as related, yet different representations of the same underlying network structure. A reaction-advection- diffusion system is used here to show that this coupling affects the transport and localization of a passive tracer in a confined geometry. For sufficiently low diffusion, cargo localization to a target zone is optimized either by low reaction kinetics and decoupling of bound and unbound states, or by a mostly disordered cytoskeletal network with only weak directional bias. These generic results may help to rationalize subtle features of cytoskeletal networks, for example as observed for microtubules in fly oocytes. © 2012 American Physical Society.
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APA:
Trong, P.K., Guck, J., & Goldstein, R.E. (2012). Coupling of active motion and advection shapes intracellular cargo transport. Physical Review Letters, 109(2). https://doi.org/10.1103/PhysRevLett.109.028104
MLA:
Trong, Philipp Khuc, Jochen Guck, and Raymond E. Goldstein. "Coupling of active motion and advection shapes intracellular cargo transport." Physical Review Letters 109.2 (2012).
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