Sensitivity of tissue shear stiffness to pressure and perfusion in health and disease
Dittmann F, Braun J, Guo J (2018)
Publication Type: Authored book
Publication year: 2018
Publisher: Springer International Publishing
ISBN: 9783319659244
DOI: 10.1007/978-3-319-65924-4_20
Abstract
This chapter discusses the sensitivity of the complex shear modulus to changes in pressure and perfusion under both physiological and pathological conditions. Biological tissue is considered an effective medium where fluid and solid phases are incorporated on a microscopic scale. The complex relationship between pressure/ perfusion and effective tissue stiffness measured by elastography has so far been investigated in abdominal organs and the brain. In the abdomen, postprandial variations in hepatic and splenic stiffness were observed in both healthy subjects and patients with liver fibrosis. In patients with portal hypertension, elevated stiffness was observed in both the liver and spleen, which instantly decreased after portal decompression. Reduced renal stiffness in patients with chronic kidney disease was found to be related to impaired renal perfusion. In the brain, different stiffness values were obtained in different gray matter regions due to their distinct perfusion characteristics. Preliminary experiments with hypercapnia or jugular compression resulted in elevated brain stiffness most likely due to increased intracranial pressure. As shear stiffness has shown sensitivity to pressure and perfusion variations associated with changes in physiological and pathological conditions, it could be used as a parameter for noninvasive assessment of pressure and perfusion. However, as confounding factors, pressure and perfusion could mask other pathologies and bias the interpretation of stiffness, which reduces diagnostic accuracy. To avoid misinterpretation, potential effects of perfusion and pressure on shear stiffness measured by elastography must be disentangled and controlled by standardized measurement protocols.
Involved external institutions
Germany (DE)How to cite
APA:
Dittmann, F., Braun, J., & Guo, J. (2018). Sensitivity of tissue shear stiffness to pressure and perfusion in health and disease. Springer International Publishing.
MLA:
Dittmann, Florian, Jürgen Braun, and Jing Guo. Sensitivity of tissue shear stiffness to pressure and perfusion in health and disease. Springer International Publishing, 2018.
BibTeX: Download