Reiter R, Shahryari M, Tzschatzsch H, Klatt D, Siegmund B, Hamm B, Braun J, Sack I, Asbach P (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 11
Article Number: 9820
Journal Issue: 1
DOI: 10.1038/s41598-021-89372-4
Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis (PSC) in comparison to viral hepatitis was assessed as a potential new biomarker using MR elastography (MRE). In this proof-of-concept study, we hypothesized a rather increased heterogeneity in PSC and a rather homogeneous distribution in viral hepatitis. Forty-six consecutive subjects (PSC: n = 20, viral hepatitis: n = 26) were prospectively enrolled between July 2014 and April 2017. Subjects underwent multifrequency MRE (1.5 T) using drive frequencies of 35–60 Hz and generating shear-wave speed (SWS in m/s) maps as a surrogate of stiffness. The coefficient of variation (CV in %) was determined to quantify fibrosis heterogeneity. Mean SWS and CV were 1.70 m/s and 21% for PSC, and 1.84 m/s and 18% for viral hepatitis. Fibrosis heterogeneity was significantly increased for PSC (P = 0.04) while no difference was found for SWS of PSC and viral hepatitis (P = 0.17). Global hepatic stiffness was similar in PSC and viral hepatitis groups, but spatial heterogeneity may reveal spatial patterns of stiffness changes towards enhanced biophysics-based diagnosis by MRI.
APA:
Reiter, R., Shahryari, M., Tzschatzsch, H., Klatt, D., Siegmund, B., Hamm, B.,... Asbach, P. (2021). Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis vs. viral hepatitis assessed by MR elastography. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-89372-4
MLA:
Reiter, Rolf, et al. "Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis vs. viral hepatitis assessed by MR elastography." Scientific Reports 11.1 (2021).
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