Real-time MR elastography for viscoelasticity quantification in skeletal muscle during dynamic exercises
Schrank F, Warmuth C, Goerner S, Meyer T, Tzschaetzsch H, Guo J, Uca YO, Elgeti T, Braun J, Sack I (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 84
Pages Range: 103-114
Journal Issue: 1
DOI: 10.1002/mrm.28095
Abstract
Purpose: To develop and test real-time MR elastography for viscoelastic parameter quantification in skeletal muscle during dynamic exercises. Methods: In 15 healthy participants, 6 groups of lower-leg muscles (tibialis anterior, tibialis posterior, peroneus, extensor digitorum longus, soleus, gastrocnemius) were investigated by real-time MR elastography using a single-shot, steady-state spiral gradient-echo pulse sequence and stroboscopic undersampling of harmonic vibrations at 40 Hz frequency. One hundred and eighty consecutive maps of shear-wave speed and loss angle (φ) covering 30.6 s of total acquisition time at 5.9-Hz frame rate were reconstructed from 360 wave images encoding 2 in-plane wave components in an interleaved manner. The experiment was carried out twice to investigate 2 exercises—isometric plantar flexion and isometric dorsiflexion—each performed over 10 s between 2 resting periods. Results: Activation of lower-extremity muscles was associated with increasing viscoelastic parameters shear-wave speed and φ, both reflecting properties related to the transverse direction relative to fiber orientation. Major viscoelastic changes were observed in soleus muscle during plantar flexion (shear-wave speed: 20.0% ± 3.6%, φ: 41.3% ± 12.0%) and in the tibialis anterior muscle during dorsiflexion (41.8% ± 10.2%, φ: 27.9% ± 2.8%; all P <.0001). Two of the muscles analyzed were significantly activated by plantar flexion and 4 by dorsiflexion based on shear-wave speed, whereas φ changed significantly in 5 muscles during both exercises. Conclusion: Real-time MR elastography allows mapping of dynamic, nonperiodic viscoelasticity changes in soft tissues such as voluntary muscle with high spatial and temporal resolution. Real-time MR elastography thus opens new horizons for the in vivo study of physiological processes in soft tissues toward functional elastography.
Involved external institutions
Germany (DE)How to cite
APA:
Schrank, F., Warmuth, C., Goerner, S., Meyer, T., Tzschaetzsch, H., Guo, J.,... Sack, I. (2020). Real-time MR elastography for viscoelasticity quantification in skeletal muscle during dynamic exercises. Magnetic Resonance in Medicine, 84(1), 103-114. https://doi.org/10.1002/mrm.28095
MLA:
Schrank, Felix, et al. "Real-time MR elastography for viscoelasticity quantification in skeletal muscle during dynamic exercises." Magnetic Resonance in Medicine 84.1 (2020): 103-114.
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