Mohtashamdolatshahi A, Kratz H, Kosch O, Hauptmann R, Stolzenburg N, Wiekhorst F, Sack I, Hamm B, Taupitz M, Schnorr J (2020)
Publication Type: Journal article
Publication year: 2020
Book Volume: 10
Article Number: 17247
Journal Issue: 1
DOI: 10.1038/s41598-020-74151-4
Magnetic Particle Imaging (MPI) is a new imaging modality, which maps the distribution of magnetic nanoparticles (MNP) in 3D with high temporal resolution. It thus may be suited for cardiovascular imaging. Its sensitivity and spatial resolution critically depend on the magnetic properties of MNP. Therefore, we used novel multicore nanoparticles (MCP 3) for in-vivo MPI in rats and analyzed dose requirements, sensitivity and detail resolution. 8 rats were examined using a preclinical MPI scanner (Bruker Biospin GmbH, Germany) equipped with a separate receive coil. MCP 3 and Resovist were administered intravenously (i.v.) into the rats’ tail veins at doses of 0.1, 0.05 and 0.025 mmol Fe/kg followed by serial MPI acquisition with a temporal resolution of 46 volumes per second. Based on a qualitative visual scoring system MCP 3–MPI images showed a significantly (P ≤ 0.05) higher image quality than Resovist-MPI images. Morphological features such as vessel lumen diameters (D
APA:
Mohtashamdolatshahi, A., Kratz, H., Kosch, O., Hauptmann, R., Stolzenburg, N., Wiekhorst, F.,... Schnorr, J. (2020). In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-74151-4
MLA:
Mohtashamdolatshahi, Azadeh, et al. "In vivo magnetic particle imaging: angiography of inferior vena cava and aorta in rats using newly developed multicore particles." Scientific Reports 10.1 (2020).
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